Toxicity-Attenuated Glycol Chitosan Adhesive Inspired by Mussel Adhesion Mechanisms

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dc.contributor.authorPark, Eunsookko
dc.contributor.authorLee, Jeeheeko
dc.contributor.authorHuh, Kang Mooko
dc.contributor.authorLee, Soo Hyeonko
dc.contributor.authorLee, Haeshinko
dc.date.accessioned2019-08-21T06:20:11Z-
dc.date.available2019-08-21T06:20:11Z-
dc.date.created2019-08-19-
dc.date.created2019-08-19-
dc.date.issued2019-07-
dc.identifier.citationADVANCED HEALTHCARE MATERIALS, v.8, no.14-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10203/264348-
dc.description.abstractChitosan-catechol, inspired from mussel-adhesive-proteins, is characterized by the formation of an adhesive membrane complex through instant bonding with serum proteins not found in chitosan. Using this intrinsic property, chitosan-catechol is widely applied for hemostatic needles, general hemostatic materials, nanoparticle composites, and 3D printing. Despite its versatility, the practical use of chitosan-catechol in the clinic is limited due to its undesired immune responses. Herein, a catechol-conjugated glycol chitosan is proposed as an alternative hemostatic hydrogel with negligible immune responses enabling the replacement of chitosan-catechol. Comparative cellular toxicity and in vivo skin irritation between chitosan-catechol and glycol chitosan-catechol are evaluated. Their immune responses are also assessed using histological analysis after subcutaneous implantation into mice. The results show that glycol chitosan-catechol significantly attenuates the immune response compared with chitosan-catechol; this finding is likely due to the antibiofouling effect of ethylene glycol groups and the reduced adhesion of immune cells. Finally, the tissue adhesion and hemostatic ability of glycol chitosan-catechol hydrogels reveal that these ethylene glycol groups do not dramatically modify the adhesiveness and hemostatic ability compared with nonglycol chitosan-catechol. This study suggests that glycol chitosan-catechol can be a promising alternative to chitosan-catechol in various biomedical fields such as hemostatic agents.-
dc.languageEnglish-
dc.publisherWILEY-
dc.titleToxicity-Attenuated Glycol Chitosan Adhesive Inspired by Mussel Adhesion Mechanisms-
dc.typeArticle-
dc.identifier.wosid000477042600008-
dc.identifier.scopusid2-s2.0-85065963115-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.issue14-
dc.citation.publicationnameADVANCED HEALTHCARE MATERIALS-
dc.identifier.doi10.1002/adhm.201900275-
dc.contributor.localauthorLee, Haeshin-
dc.contributor.nonIdAuthorLee, Jeehee-
dc.contributor.nonIdAuthorHuh, Kang Moo-
dc.contributor.nonIdAuthorLee, Soo Hyeon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorchitosan-
dc.subject.keywordAuthorglycol chitosan-
dc.subject.keywordAuthorhemostasis-
dc.subject.keywordAuthorhydrogels-
dc.subject.keywordAuthorimmunotoxicity-
dc.subject.keywordPlusANTIFOULING ORGANOSILANE ADLAYERS-
dc.subject.keywordPlusLOW-MOLECULAR-WEIGHT-
dc.subject.keywordPlusSURFACE-CHEMISTRY-
dc.subject.keywordPlusTRANSFECTION EFFICIENCY-
dc.subject.keywordPlusSOLUBLE CHITOSAN-
dc.subject.keywordPlusETHYLENE-GLYCOL-
dc.subject.keywordPlusCATECHOL-
dc.subject.keywordPlusHYDROGELS-
dc.subject.keywordPlusPOLYMER-
dc.subject.keywordPlusNANOPARTICLES-
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