DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Soojeong | ko |
dc.contributor.author | Min, Nam Gi | ko |
dc.contributor.author | Park, Wooram | ko |
dc.contributor.author | Kim, Shin-Hyun | ko |
dc.contributor.author | Kim, Dong-Hyun | ko |
dc.date.accessioned | 2019-08-20T06:20:54Z | - |
dc.date.available | 2019-08-20T06:20:54Z | - |
dc.date.created | 2019-08-19 | - |
dc.date.created | 2019-08-19 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | ADVANCED FUNCTIONAL MATERIALS, v.29, no.26 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | http://hdl.handle.net/10203/264341 | - |
dc.description.abstract | Combination chemotherapy administering multiple chemo agents is widely exploited for the treatment of various cancers in the clinic. Specially for hepatocellular carcinoma (HCC), one of the most common malignancies, a coadministration of combinational cytostatic multikinase inhibitors and cytotoxic chemo agents has been suggested as a potential curative approach. Here, Janus microcarriers are developed for the controlled local combination chemotherapy of HCC. The Janus microcarriers are composed of a polycaprolactone (PCL) compartment and a magnetic nanoparticle-loaded poly(lactide-co-glycolic acid) (PLGA) compartment which contains hydrophobic regorafenib and hydrophilic doxorubicin, respectively. Exploiting the magnetic anisotropy, rotational motion of the Janus microcarriers is controlled with a magnetic field, which enables the active corelease of dual chemo agents. Furthermore, Janus microcarriers exhibit magnetic resonance (MR) contrast effect, supporting the successful transcatheter intra-arterial delivery of the combination chemo agents loaded in the microcarriers to the targeted tumor. This Janus microcarrier potentially serves as a general combinational chemotherapeutic platform for the codelivery of various combinations of multichemo agents. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Janus Microcarriers for Magnetic Field-Controlled Combination Chemotherapy of Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.identifier.wosid | 000478617900024 | - |
dc.identifier.scopusid | 2-s2.0-85065187273 | - |
dc.type.rims | ART | - |
dc.citation.volume | 29 | - |
dc.citation.issue | 26 | - |
dc.citation.publicationname | ADVANCED FUNCTIONAL MATERIALS | - |
dc.identifier.doi | 10.1002/adfm.201901384 | - |
dc.contributor.localauthor | Kim, Shin-Hyun | - |
dc.contributor.nonIdAuthor | Cho, Soojeong | - |
dc.contributor.nonIdAuthor | Park, Wooram | - |
dc.contributor.nonIdAuthor | Kim, Dong-Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | drug release | - |
dc.subject.keywordAuthor | Janus microcarriers | - |
dc.subject.keywordAuthor | liver cancer | - |
dc.subject.keywordAuthor | magnetic response | - |
dc.subject.keywordPlus | TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | TRANSARTERIAL CHEMOEMBOLIZATION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | SORAFENIB | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | HCC | - |
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