Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)–amyloid-b

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We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound amyloid-beta [ Zn(II)-A beta], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(II) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(II)-A beta (phen, 1, and 2), or both (3).
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2019-05
Language
English
Article Type
Article
Citation

CHEMICAL COMMUNICATIONS, v.55, no.42, pp.5847 - 5850

ISSN
1359-7345
DOI
10.1039/c9cc01005j
URI
http://hdl.handle.net/10203/262492
Appears in Collection
CH-Journal Papers(저널논문)
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