Nucleic acid-based fluorescent methods for the determination of DNA repair enzyme activities

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DNA repair pathways are closely associated with the maintenance of genomic integrity, disease outbreak, and the development of therapeutics. Owing to these significances, novel analytical methods for enzymes that are involved in the DNA repair pathways have been actively investigated. This review focuses on discussions on nucleic acid-based methods, especially those based on the fluorescence, for the determination of DNA repair enzymes. Furthermore, this review not only provides meaningful insights in creating ingenious fluorescent detection methods but it also suggests future directions that will be followed in developing new analytical technologies for the DNA repair enzymes. (C) 2019 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2019-07
Language
English
Article Type
Review
Citation

ANALYTICA CHIMICA ACTA, v.1060, pp.30 - 44

ISSN
0003-2670
DOI
10.1016/j.aca.2018.12.055
URI
http://hdl.handle.net/10203/253911
Appears in Collection
CBE-Journal Papers(저널논문)
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