DC Field | Value | Language |
---|---|---|
dc.contributor.author | Le, Thien-Kim | ko |
dc.contributor.author | Park, Jong Hyun | ko |
dc.contributor.author | Choi, Da Som | ko |
dc.contributor.author | Lee, Ga-Young | ko |
dc.contributor.author | Choi, Woo Sung | ko |
dc.contributor.author | Jeong, Ki Jun | ko |
dc.contributor.author | Park, Chan Beum | ko |
dc.contributor.author | Yun, Chul-Ho | ko |
dc.date.accessioned | 2019-03-19T01:26:45Z | - |
dc.date.available | 2019-03-19T01:26:45Z | - |
dc.date.created | 2018-12-06 | - |
dc.date.created | 2018-12-06 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | GREEN CHEMISTRY, v.21, no.3, pp.515 - 525 | - |
dc.identifier.issn | 1463-9262 | - |
dc.identifier.uri | http://hdl.handle.net/10203/251643 | - |
dc.description.abstract | Despite the immense potential of P450s, the dependence on the nicotinamide cofactor (NADPH) and NADPH-P450 reductase (CPR) limits their employment in the chemical industry. Here, we present a visible light-driven platform for biocatalytic C-hydroxylation reactions using natural flavin molecules, especially flavin mononucleotide, as a photosensitizer. By employing visible light as a source of energy instead of the nicotinamide cofactor, the bacterial CYP102A1 heme domain was successfully applied for photobiocatalytic C-hydroxylation of 4-nitrophenol and lauric acid – in the absence of NADPH and CPR. We present a proof of concept that the photoactivation of flavins is productively coupled with the direct transfer of photoinduced electrons to the P450 heme iron, achieving photobiocatalytic C-hydroxylation reactions. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Solar-Driven Biocatalytic C-Hydroxylation through Direct Transfer of Photoinduced Electrons | - |
dc.type | Article | - |
dc.identifier.wosid | 000457794700032 | - |
dc.identifier.scopusid | 2-s2.0-85061175236 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 515 | - |
dc.citation.endingpage | 525 | - |
dc.citation.publicationname | GREEN CHEMISTRY | - |
dc.identifier.doi | 10.1039/C8GC02398K | - |
dc.contributor.localauthor | Jeong, Ki Jun | - |
dc.contributor.localauthor | Park, Chan Beum | - |
dc.contributor.nonIdAuthor | Le, Thien-Kim | - |
dc.contributor.nonIdAuthor | Lee, Ga-Young | - |
dc.contributor.nonIdAuthor | Yun, Chul-Ho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HUMAN METABOLITES | - |
dc.subject.keywordPlus | P450 BM3 | - |
dc.subject.keywordPlus | CYTOCHROME-P450 SYSTEMS | - |
dc.subject.keywordPlus | CARBENE TRANSFER | - |
dc.subject.keywordPlus | ENZYME-ACTIVITY | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | CYP102A1 | - |
dc.subject.keywordPlus | PROTOTYPE | - |
dc.subject.keywordPlus | FLAVINS | - |
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