DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Dong Sun | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.contributor.author | Kim, Heegon | ko |
dc.contributor.author | Oh, Ji Eun | ko |
dc.contributor.author | Jung, Hi Eun | ko |
dc.contributor.author | Park, Ji-Ho | ko |
dc.date.accessioned | 2019-01-23T05:25:35Z | - |
dc.date.available | 2019-01-23T05:25:35Z | - |
dc.date.created | 2018-12-13 | - |
dc.date.issued | 2018-09-30 | - |
dc.identifier.citation | CRI-CIMT-EATI-AACR FOURTH INTERNATIONAL CANCER IMMUNOTHERAPY CONFERENCE | - |
dc.identifier.uri | http://hdl.handle.net/10203/249411 | - |
dc.description.abstract | Tumor immunotherapy aims to overcome the immunosuppressive microenvironment within tumors, and various approaches have been developed. Tumor-associated T regulatory cells (Tregs) suppress the activation and expansion of tumor antigen-specific effector T cells, thus, providing a permissive environment for tumor growth. Therefore, optimal strategies need to be established to deplete tumor-infiltrated Tregs because systemic depletion of Tregs can result in reduced anti-tumor effector cells and autoimmunity. Here, to deplete Tregs selectively in tumors, we intratumorally injected anti-CD25 antibodies conjugated to Chlorin e6 (Ce6), a photosensitizer that absorbs light to generate reactive oxygen species. Local depletion of tumor-associated Tregs by photodynamic therapy (PDT) inhibited tumor growth, which was likely due to the altered tumor immune microenvironment that was characterized by increased infiltration of CD8+ effector T cells and the expression of IFN-γ and CD107a, which is cytolytic granule exocytosis marker, in tumor tissues. Furthermore, PDT-induced intratumoral Treg depletion did not influence adaptive immune responses in a murine influenza infection model. Thus, our results show that intratumoral Treg-targeted PDT could specifically modulate tumor microenvironments by depleting Tregs and could be used as a novel cancer immunotherapy technique. Keywords: Photodynamic therapy, Treg, CD25, Chlorin e6 | - |
dc.language | English | - |
dc.publisher | INTERNATIONAL CANCER IMMUNOTHERAPY CONFERENCE | - |
dc.title | Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy induces anti-tumoral immune responses | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | CRI-CIMT-EATI-AACR FOURTH INTERNATIONAL CANCER IMMUNOTHERAPY CONFERENCE | - |
dc.identifier.conferencecountry | US | - |
dc.identifier.conferencelocation | New York Marriott Marquis | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
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