A mathematical model of intracellular behavior of microalgae for predicting growth and intracellular components syntheses under nutrient-replete and -deplete conditions

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Microalgae is a promising biomass source for renewable fuels and chemicals production. To describe microalgal behavior and improve their cultivation, various kinetic models have been proposed. However, previous works have focused on biomass formation and lipids production only, even though carbohydrates and proteins are also important products, not only for understanding the metabolic behavior of microalgae but also for enhancing the economic viability through value-added side products. In this study, a new mathematical model is proposed to explain core biological mechanisms of growth and macromolecules syntheses based on the central metabolism of carbon and nitrogen. In the model, microalgal growth is separated as hyperplasia and hypertrophy, to describe the cell growth more precisely under nutrient-replete and -deplete conditions. Sensitivity analysis performed using the model indicates that cell state (e.g., cell death rate) has a strong effect on the lipid production explaining the difficulty of reproducing a microalgae culture experiment.
Publisher
WILEY
Issue Date
2018-10
Language
English
Article Type
Article
Citation

BIOTECHNOLOGY AND BIOENGINEERING, v.115, no.10, pp.2441 - 2455

ISSN
0006-3592
DOI
10.1002/bit.26744
URI
http://hdl.handle.net/10203/246550
Appears in Collection
CBE-Journal Papers(저널논문)
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