It's fun to transcribe with Fun30: A model for nucleosome dynamics during RNA polymerase II-mediated elongation

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The ability of elongating RNA polymerase II (RNAPII) to regulate the nucleosome barrier is poorly understood because we do not know enough about the involved factors and we lack a conceptual framework to model this process. Our group recently identified the conserved Fun30/SMARCAD1 family chromatin-remodeling factor, Fun30(Fft3), as being critical for relieving the nucleosome barrier during RNAPII-mediated elongation, and proposed a model illustrating how Fun30(Fft3) may contribute to nucleosome disassembly during RNAPII-mediated elongation. Here, we present a model that describes nucleosome dynamics during RNAPII-mediated elongation in mathematical terms and addresses the involvement of Fun30(Fft3) in this process.
Publisher
TAYLOR & FRANCIS INC
Issue Date
2018-07
Language
English
Article Type
Review
Keywords

DNA END RESECTION; FACTORS REPRESS TRANSCRIPTION; CHROMATIN-REMODELING ENZYME; HISTONE EXCHANGE; IN-VIVO; FACT; REPLICATION; INITIATION; GENOME; YEAST

Citation

TRANSCRIPTION-AUSTIN, v.9, no.2, pp.108 - 116

ISSN
2154-1264
DOI
10.1080/21541264.2017.1356434
URI
http://hdl.handle.net/10203/244676
Appears in Collection
BS-Journal Papers(저널논문)
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