Hippocampal Subfields Volume Reduction in High Schoolers with Previous Verbal Abuse Experiences

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Objective: Reduced hippocampal volume and alterations in white matter tracts have been frequently reported in adults having the history of emotional maltreatment. We investigated whether these structural change occur in adolescents with previous verbal abuse (VA) experiences. Methods: Hippocampal subfield volume and white matter structural connectivity measures were assessed in 31 first year male high school students with various degrees of exposure to parental and peer VA. Results: The high VA group showed significant volume reduction in the left cornu ammonis (CA) 1 and left subiculum compared to the low VA group (p<0.05). Volumes of left hippocampal subfields CA1 and subiculum were negatively correlated with previous VA experiences (p<0.05). Increased mean diffusivity (MD) of the splenium of the corpus callosum was related to high VA score across all subjects (p<0.05). There was an inverse relationship between volume of the CA1 and subiculum and MD of the splenium (p<0.05). Conclusion: Exposure to parental and peer VA may affect development of the left hippocampal subfields and the splenium of corpus callosum. These structural alterations can be discernible during adolescence.
Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
Issue Date
2018-02
Language
English
Article Type
Article
Keywords

POSTTRAUMATIC-STRESS-DISORDER; MAGNETIC-RESONANCE IMAGES; CHILDHOOD SEXUAL-ABUSE; SURFACE-BASED ANALYSIS; GRAY-MATTER VOLUME; IN-VIVO MRI; CORPUS-CALLOSUM; WHITE-MATTER; CORTICAL SURFACE; FRACTIONAL ANISOTROPY

Citation

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.16, no.1, pp.46 - 56

ISSN
1738-1088
DOI
10.9758/cpn.2018.16.1.46
URI
http://hdl.handle.net/10203/240723
Appears in Collection
EE-Journal Papers(저널논문)MSE-Journal Papers(저널논문)
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