Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons

Manganese, iron, copper, and zinc are observed to play essential roles in mitochondria. The overload and depletion of metal ions in mitochondria under pathological conditions, however, could disturb mitochondrial compartments and functions leading to cell death. In this review, we mainly summarize how impaired metal ion homeostasis affects mitochondrial systems, such as membrane potentials, the tricarboxylic acid cycle, oxidative phosphorylation, and glutathione metabolism. In addition, based on current findings, we briefly describe a recent understanding of the relationship among metal ion dysregulation, mitochondrial dysfunction, and the pathogeneses of neurodegenerative diseases.
Publisher
Elsevier Ltd
Issue Date
2018-04
Language
English
Citation

Current Opinion in Chemical Biology, v.43, pp.8 - 14

ISSN
1367-5931
DOI
10.1016/j.cbpa.2017.09.009
URI
http://hdl.handle.net/10203/240193
Appears in Collection
CH-Journal Papers(저널논문)
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