Organ-specific lymphatic vasculature: From development to pathophysiology

Cited 22 time in webofscience Cited 0 time in scopus
  • Hit : 271
  • Download : 0
Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues. This review aims to summarize the most recent findings of organotypic differentiation of lymphatic endothelial cells in terms of their distinct (patho) physiological functions in skin, lymph nodes, small intestine, brain, and eye. We discuss recent advances in our understanding of the heterogeneity of lymphatic vessels with respect to the organ-specific functional and molecular specialization of lymphatic endothelium, such as the hybrid blood-lymphatic identity of Schlemm's canal, functions of intestinal lymphatics in dietary fat uptake, and discovery of meningeal lymphatic vasculature and perivascular brain lymphatic endothelial cells.
Publisher
ROCKEFELLER UNIV PRESS
Issue Date
2018-01
Language
English
Article Type
Review
Keywords

CENTRAL-NERVOUS-SYSTEM; PLURIPOTENT STEM-CELLS; NODE STROMAL CELLS; ENDOTHELIAL-CELLS; DENDRITIC CELLS; LYMPHOCYTE EGRESS; GENE-EXPRESSION; T-CELLS; VEGF-C; VESSELS

Citation

JOURNAL OF EXPERIMENTAL MEDICINE, v.215, no.1, pp.35 - 49

ISSN
0022-1007
DOI
10.1084/jem.20171868
URI
http://hdl.handle.net/10203/239455
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 22 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0