DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, IJ | ko |
dc.contributor.author | Lee, HW | ko |
dc.contributor.author | Park, CH | ko |
dc.contributor.author | Lee, SangYup | ko |
dc.contributor.author | Lee, J | ko |
dc.date.accessioned | 2011-03-14T07:35:58Z | - |
dc.date.available | 2011-03-14T07:35:58Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.18, no.5, pp.908 - 912 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | http://hdl.handle.net/10203/22624 | - |
dc.description.abstract | To achieve a higher succinic acid productivity and evaluate the industrial applicability, this study used Mannheimia succiniciproducens LPK7 (knock-out: ldhA, pflB, pta-ackA), which was recently designed to enhance the productivity of succinic acid and reduce by-product secretion. Anaerobic continuous fermentation of Mannheimia succiniciproducens LPK7 was carried out at different glucose feed concentrations and dilution rates. After extensive fermentation experiments, a succinic acid yield and productivity of 0.38 mol/mol and 1.77 g/l/h, respectively, were achieved with a glucose feed concentration of 18.0 g/l and 0.2 h(-1) dilution rate. A similar amount of succinic acid production was also produced in batch culture experiments. Therefore, these optimal conditions can be industrially applied for the continuous production of succinic acid. To examine the quantitative balance of the metabolism, a flux distribution analysis was also performed using the metabolic network model of glycolysis and the pentose phosphate pathway. | - |
dc.description.sponsorship | Our work was supported by the Genome-Based Integrated Bioprocess Development Project from the Korean Ministry of Science and Technology (No. 2005-01304) through the Korea Science and Engineering Foundation (KOSEF). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.title | Succinic acid production by continuous fermentation process using Mannheimia succiniciproducens LPK7 | - |
dc.type | Article | - |
dc.identifier.wosid | 000256238100016 | - |
dc.identifier.scopusid | 2-s2.0-50249161426 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 908 | - |
dc.citation.endingpage | 912 | - |
dc.citation.publicationname | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, SangYup | - |
dc.contributor.nonIdAuthor | Oh, IJ | - |
dc.contributor.nonIdAuthor | Lee, HW | - |
dc.contributor.nonIdAuthor | Park, CH | - |
dc.contributor.nonIdAuthor | Lee, J | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Mannheimia succiniciproducens LPK7 | - |
dc.subject.keywordAuthor | continuous fermentation | - |
dc.subject.keywordAuthor | succinic acid | - |
dc.subject.keywordAuthor | flux distribution analysis | - |
dc.subject.keywordPlus | ANAEROBIOSPIRILLUM-SUCCINICIPRODUCENS | - |
dc.subject.keywordPlus | WOOD HYDROLYSATE | - |
dc.subject.keywordPlus | BACTERIUM | - |
dc.subject.keywordPlus | RUMEN | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.