Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus

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dc.contributor.authorKim, Jeongjinko
dc.contributor.authorKim, Youngsooko
dc.contributor.authorNakajima, Ryuichiko
dc.contributor.authorShin, Annako
dc.contributor.authorJeong, Minjuko
dc.contributor.authorPark, Ah-Hyungko
dc.contributor.authorJeong, Yongcheolko
dc.contributor.authorJo, Seonmiko
dc.contributor.authorYang, Seungkyoungko
dc.contributor.authorPark, Hosungko
dc.contributor.authorCho, Sung-Hwanko
dc.contributor.authorCho, Kwang-Hyunko
dc.contributor.authorShim, Insopko
dc.contributor.authorChung, Jae-Hoonko
dc.contributor.authorPaik, Se-Bumko
dc.contributor.authorAugustine, George J.ko
dc.contributor.authorKim, Daesooko
dc.date.accessioned2017-09-25T06:03:09Z-
dc.date.available2017-09-25T06:03:09Z-
dc.date.created2017-09-18-
dc.date.created2017-09-18-
dc.date.created2017-09-18-
dc.date.issued2017-08-
dc.identifier.citationNEURON, v.95, no.5, pp.1181 - +-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://hdl.handle.net/10203/226143-
dc.description.abstractBasal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca2+ channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectSEPIAPTERIN-REDUCTASE DEFICIENCY-
dc.subjectLATERAL GENICULATE-NUCLEUS-
dc.subjectDEEP BRAIN-STIMULATION-
dc.subjectNIGRA PARS RETICULATA-
dc.subjectPARKINSONS-DISEASE-
dc.subjectCA2+ CHANNELS-
dc.subjectGLOBUS-PALLIDUS-
dc.subjectPATHOLOGICAL SYNCHRONIZATION-
dc.subjectEFFERENT CONNECTIONS-
dc.subjectSUBTHALAMIC NUCLEUS-
dc.titleInhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus-
dc.typeArticle-
dc.identifier.wosid000408687900022-
dc.identifier.scopusid2-s2.0-85028612757-
dc.type.rimsART-
dc.citation.volume95-
dc.citation.issue5-
dc.citation.beginningpage1181-
dc.citation.endingpage+-
dc.citation.publicationnameNEURON-
dc.identifier.doi10.1016/j.neuron.2017.08.028-
dc.contributor.localauthorCho, Kwang-Hyun-
dc.contributor.localauthorChung, Jae-Hoon-
dc.contributor.localauthorPaik, Se-Bum-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.nonIdAuthorNakajima, Ryuichi-
dc.contributor.nonIdAuthorYang, Seungkyoung-
dc.contributor.nonIdAuthorShim, Insop-
dc.contributor.nonIdAuthorAugustine, George J.-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSEPIAPTERIN-REDUCTASE DEFICIENCY-
dc.subject.keywordPlusLATERAL GENICULATE-NUCLEUS-
dc.subject.keywordPlusDEEP BRAIN-STIMULATION-
dc.subject.keywordPlusNIGRA PARS RETICULATA-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusGLOBUS-PALLIDUS-
dc.subject.keywordPlusPATHOLOGICAL SYNCHRONIZATION-
dc.subject.keywordPlusEFFERENT CONNECTIONS-
dc.subject.keywordPlusSUBTHALAMIC NUCLEUS-
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