Nerve agent simulant diethyl chlorophosphate detection using a cyclization reaction approach with high stokes shift system

Cited 14 time in webofscience Cited 0 time in scopus
  • Hit : 301
  • Download : 0
A reaction-based fluorescent probe (CoumNMe(2)) containing a coumarin-4-dimethyaminoaryl scaffold for the detection of nerve agent simulants was developed. The probe showed fluorescence enhancement selectively with diethyl chlorophosphate (DCP) over close competitors diethyl cyanophosphonate (DECP), and diethyl methylphosphonate (DEMP) with very little interference from metal ions. O-P bond formation by reaction of the benzyl alcohol motif on the probe with DCP, favours intramolecular cyclization that leads to the ammonium salt. The cyclization strongly inhibits the photo-induced electron transfer (PET) process, which leads to the enhancement of fluorescence intensity (similar to 10 fold). Also, DFT/TDDFT calculations were exploited to explain the nature of the fluorescence '' turn-on'' process. Herein, we report a new fluorescent probe (CoumNMe2) based on the intramolecular cyclization reaction for the detection of nerve agent simulant and has potential for real applications.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2017
Language
English
Article Type
Article
Keywords

CHEMICAL WARFARE AGENTS; VAPOR-PHASE DETECTION; DEGRADATION-PRODUCTS; VISUAL DETECTION; MIMICS; DISCRIMINATION; TABUN; DCP; LIQUID; SARIN

Citation

NEW JOURNAL OF CHEMISTRY, v.41, no.4, pp.1653 - 1658

ISSN
1144-0546
DOI
10.1039/c6nj03712g
URI
http://hdl.handle.net/10203/222790
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 14 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0