Design, synthesis and self-assembly properties of $\alpha$-peptide building block containing aib residues = Aib 단위체를 포함한 알파-펩타이드 빌딩블록의 설계, 합성 및 자기조립 특성에 관한 연구

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Hierarchical self-assembly has shown great potential in the preparation of high dimensional nano/micro- biomimic materials. Numerous design strategies for building blocks have been employed to create well-defined structures. The incorporation of functionalities such as amphiphilic or aromatic groups is a well-known design principle for short $\alpha$ -peptide building blocks but most morphologies still remain in low dimensional. Therefore, the achievement of high dimensional morphologies from unmodified and flexible $\alpha$ -peptidic building blocks remains an outstanding challenge. It has been demonstrated that discrete and homogeneous two or three dimensional structures could be derived from $\beta$ -peptidic scaffolds, due mainly to the restricted conformational space of $\beta$ -peptides. Thus the same design principle should be applicable to $\alpha$ -peptides. In this thesis, conformationally constrained $\alpha$ -heptamer that contain both helix-promoting Aib ($\alpha$ -amino isobutyric acid) and Leu residues to drive hydrophobic interactions has been synthesized and characterized in the solution and solid states using NMR spectroscopy, single crystal X-ray and powder X-ray diffraction techniques. It was observed that this short $\alpha$ -peptide, which effectively populates helical secondary structures, could self-assemble to form well-defined and homogeneous two dimensional plate structures while an alanine homologue control peptide gave rise only to heterogeneous aggregated spheres. This study demonstrates that new and potentially useful building blocks are available from $\alpha$ -amino acid peptides through comprehensive molecular-level design. It is envisioned that this study will widen the choices of suitable building blocks for the design of new and useful self-assembled materials.
Advisors
Lee, Hee-Seungresearcher이희승researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2016
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 2016.2 ,[iv, 36 p. :]

Keywords

self-assembly; $\alpha$ -peptide; two dimensional plate; molecular-level design; conformational constraint; Aib ($\alpha$ -aminoisobutyric acid); 자기조립; 알파-펩타이드; 2차원 판상 구조체; 분자 수준 설계; Aib (알파-메틸알라닌)

URI
http://hdl.handle.net/10203/222064
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=649776&flag=dissertation
Appears in Collection
CH-Theses_Master(석사논문)
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