DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.contributor.author | Lee, Su-Hwa | ko |
dc.contributor.author | Choi, Won-Hyung | ko |
dc.contributor.author | Choi, Hyo-Jick | ko |
dc.contributor.author | Goo, Tae-Won | ko |
dc.contributor.author | Lee, Ju-Hie | ko |
dc.contributor.author | Quan, Fu-Shi | ko |
dc.date.accessioned | 2017-03-28T06:58:20Z | - |
dc.date.available | 2017-03-28T06:58:20Z | - |
dc.date.created | 2017-03-06 | - |
dc.date.created | 2017-03-06 | - |
dc.date.created | 2017-03-06 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | JOURNAL OF DRUG TARGETING, v.24, no.10, pp.943 - 951 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | http://hdl.handle.net/10203/221013 | - |
dc.description.abstract | A painless self-immunization method with effective and broad cross-protection is urgently needed to prevent infections against newly emerging influenza viruses. In this study, we investigated the cross-protection efficacy of trivalent influenza vaccine containing inactivated A/PR/8/34 (H1N1), A/Hong Kong/68 (H3N2) and B/Lee/40 after skin vaccination using microneedle patches coated with this vaccine. Microneedle vaccination of mice in the skin provided 100% protection against lethal challenges with heterologous pandemic strain influenza A/California/04/09, heterogeneous A/Philippines/2/82 and B/Victoria/287 viruses 8 months after boost immunization. Cross-reactive serum IgG antibody responses against heterologous influenza viruses A/California/04/09, A/Philippines/2/82 and B/Victoria/287 were induced at high levels. Hemagglutination inhibition titers were also maintained at high levels against these heterogeneous viruses. Microneedle vaccination induced substantial levels of cross-reactive IgG antibody responses in the lung and cellular immune responses, as well as cross-reactive antibody-secreting plasma cells in the spleen. Viral loads in the lung were significantly (p< 0.05) reduced. All mice survived after viral challenges. These results indicate that skin vaccination with trivalent vaccine using a microneedle array could provide protection against seasonal epidemic or new pandemic strain of influenza viruses. | - |
dc.language | English | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Microneedle delivery of trivalent influenza vaccine to the skin induces long-term cross-protection | - |
dc.type | Article | - |
dc.identifier.wosid | 000393188000005 | - |
dc.identifier.scopusid | 2-s2.0-84961635275 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 943 | - |
dc.citation.endingpage | 951 | - |
dc.citation.publicationname | JOURNAL OF DRUG TARGETING | - |
dc.identifier.doi | 10.3109/1061186X.2016.1159213 | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Lee, Su-Hwa | - |
dc.contributor.nonIdAuthor | Choi, Won-Hyung | - |
dc.contributor.nonIdAuthor | Choi, Hyo-Jick | - |
dc.contributor.nonIdAuthor | Goo, Tae-Won | - |
dc.contributor.nonIdAuthor | Lee, Ju-Hie | - |
dc.contributor.nonIdAuthor | Quan, Fu-Shi | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Influenza | - |
dc.subject.keywordAuthor | microneedle | - |
dc.subject.keywordAuthor | protection | - |
dc.subject.keywordAuthor | trivalent vaccine | - |
dc.subject.keywordPlus | VIRUS-LIKE PARTICLES | - |
dc.subject.keywordPlus | MUCOSAL IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | IMMUNIZATION | - |
dc.subject.keywordPlus | H1N1 | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | H5N1 | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | PROSPECTS | - |
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