DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kurz, Angela R. M. | ko |
dc.contributor.author | Pruenster, Monika | ko |
dc.contributor.author | Rohwedder, Ina | ko |
dc.contributor.author | Ramadass, Mahalakshmi | ko |
dc.contributor.author | Schaefer, Kerstin | ko |
dc.contributor.author | Harrison, Ute | ko |
dc.contributor.author | Gouveia, Gabriel | ko |
dc.contributor.author | Nussbaum, Claudia | ko |
dc.contributor.author | Immler, Roland | ko |
dc.contributor.author | Wiessner, Johannes R. | ko |
dc.contributor.author | Margraf, Andreas | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.contributor.author | Walzog, Barbara | ko |
dc.contributor.author | Dietzel, Steffen | ko |
dc.contributor.author | Moser, Markus | ko |
dc.contributor.author | Klein, Christoph | ko |
dc.contributor.author | Vestweber, Dietmar | ko |
dc.contributor.author | Haas, Rainer | ko |
dc.contributor.author | Catz, Sergio D. | ko |
dc.contributor.author | Sperandio, Markus | ko |
dc.date.accessioned | 2016-12-01T07:59:26Z | - |
dc.date.available | 2016-12-01T07:59:26Z | - |
dc.date.created | 2016-11-28 | - |
dc.date.created | 2016-11-28 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | JOURNAL OF CLINICAL INVESTIGATION, v.126, no.11, pp.4125 - 4139 | - |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | http://hdl.handle.net/10203/214595 | - |
dc.description.abstract | Neutrophils need to penetrate the perivascular basement membrane for successful extravasation into inflamed tissue, but this process is incompletely understood. Recent findings have associated mammalian sterile 20-like Kinase 1 (MST1) loss of function with a human primary immunodeficiency disorder, suggesting that MST1 may be involved in immune cell migration. Here, we have shown that MST1 is a critical regulator of neutrophil extravasation during inflammation. Mst1-deficient (Mst1(-/-)) neutrophils were unable to migrate into inflamed murine cremaster muscle venules, instead persisting between the endothelium and the basement membrane. Mst1(-/-) neutrophils also failed to extravasate from gastric submucosal vessels in a murine model of Helicobacter pylori infection. Mechanistically, we observed defective translocation of VLA-3, VLA-6, and neutrophil elastase from intracellular vesicles to the surface of Mst1(-/-) neutrophils, indicating that MST1 is required for this crucial step in neutrophil transmigration. Furthermore, we found that MST1 associates with the Rab27 effector protein synaptotagmin-like protein 1 (JFC1, encoded by Sytl1 in mice), but not Munc13-4, thereby regulating the trafficking of Rab27-positive vesicles to the cellular membrane. Together, these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect observed in patients with MST1 deficiency | - |
dc.language | English | - |
dc.publisher | AMER SOC CLINICAL INVESTIGATION INC | - |
dc.subject | IN-VIVO | - |
dc.subject | LEUKOCYTE MIGRATION | - |
dc.subject | TRANSENDOTHELIAL MIGRATION | - |
dc.subject | LYMPHOCYTE TRAFFICKING | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | ACTIVATING PROTEIN | - |
dc.subject | GRANULE SECRETION | - |
dc.subject | CELL RECRUITMENT | - |
dc.subject | LAMININ ISOFORMS | - |
dc.subject | NADPH OXIDASE | - |
dc.title | MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane | - |
dc.type | Article | - |
dc.identifier.wosid | 000386992900009 | - |
dc.identifier.scopusid | 2-s2.0-84994578264 | - |
dc.type.rims | ART | - |
dc.citation.volume | 126 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 4125 | - |
dc.citation.endingpage | 4139 | - |
dc.citation.publicationname | JOURNAL OF CLINICAL INVESTIGATION | - |
dc.identifier.doi | 10.1172/JCI87043 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Kurz, Angela R. M. | - |
dc.contributor.nonIdAuthor | Pruenster, Monika | - |
dc.contributor.nonIdAuthor | Rohwedder, Ina | - |
dc.contributor.nonIdAuthor | Ramadass, Mahalakshmi | - |
dc.contributor.nonIdAuthor | Schaefer, Kerstin | - |
dc.contributor.nonIdAuthor | Harrison, Ute | - |
dc.contributor.nonIdAuthor | Gouveia, Gabriel | - |
dc.contributor.nonIdAuthor | Nussbaum, Claudia | - |
dc.contributor.nonIdAuthor | Immler, Roland | - |
dc.contributor.nonIdAuthor | Wiessner, Johannes R. | - |
dc.contributor.nonIdAuthor | Margraf, Andreas | - |
dc.contributor.nonIdAuthor | Walzog, Barbara | - |
dc.contributor.nonIdAuthor | Dietzel, Steffen | - |
dc.contributor.nonIdAuthor | Moser, Markus | - |
dc.contributor.nonIdAuthor | Klein, Christoph | - |
dc.contributor.nonIdAuthor | Vestweber, Dietmar | - |
dc.contributor.nonIdAuthor | Haas, Rainer | - |
dc.contributor.nonIdAuthor | Catz, Sergio D. | - |
dc.contributor.nonIdAuthor | Sperandio, Markus | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LEUKOCYTE MIGRATION | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | LYMPHOCYTE TRAFFICKING | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | ACTIVATING PROTEIN | - |
dc.subject.keywordPlus | GRANULE SECRETION | - |
dc.subject.keywordPlus | CELL RECRUITMENT | - |
dc.subject.keywordPlus | LAMININ ISOFORMS | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
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