Protein sequestration versus Hill-type repression in circadian clock models

Cited 22 time in webofscience Cited 0 time in scopus
  • Hit : 383
  • Download : 0
Circadian (approximate to 24 h) clocks are self-sustained endogenous oscillators with which organisms keep track of daily and seasonal time. Circadian clocks frequently rely on interlocked transcriptional-translational feedback loops to generate rhythms that are robust against intrinsic and extrinsic perturbations. To investigate the dynamics and mechanisms of the intracellular feedback loops in circadian clocks, a number of mathematical models have been developed. The majority of the models use Hill functions to describe transcriptional repression in a way that is similar to the Goodwin model. Recently, a new class of models with protein sequestration-based repression has been introduced. Here, the author discusses how this new class of models differs dramatically from those based on Hill-type repression in several fundamental aspects: conditions for rhythm generation, robust network designs and the periods of coupled oscillators. Consistently, these fundamental properties of circadian clocks also differ among Neurospora, Drosophila, and mammals depending on their key transcriptional repression mechanisms (Hill-type repression or protein sequestration). Based on both theoretical and experimental studies, this review highlights the importance of careful modelling of transcriptional repression mechanisms in molecular circadian clocks
Publisher
INST ENGINEERING TECHNOLOGY-IET
Issue Date
2016-08
Language
English
Article Type
Review
Keywords

NEGATIVE FEEDBACK LOOP; REV-ERB-ALPHA; SELF-SUSTAINED OSCILLATORS; DROSOPHILA PERIOD PROTEIN; TEMPERATURE COMPENSATION; SUPRACHIASMATIC NUCLEUS; CELL-CYCLE; MOLECULAR NOISE; INTERCELLULAR SYNCHRONIZATION; GENETIC OSCILLATIONS

Citation

IET SYSTEMS BIOLOGY, v.10, no.4, pp.125 - 135

ISSN
1751-8849
DOI
10.1049/iet-syb.2015.0090
URI
http://hdl.handle.net/10203/213236
Appears in Collection
MA-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 22 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0