T cell senescence and cardiovascular diseases

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Age-related changes in the immune system, commonly termed "immunosenescence," contribute to deterioration of the immune response and fundamentally impact the health and survival of elderly individuals. Immunosenescence affects both the innate and adaptive immune systems; however, the most notable changes are in T cell immunity and include thymic involution, the collapse of T cell receptor (TCR) diversity, an imbalance in T cell populations, and the clonal expansion of senescent T cells. Senescent T cells have the ability to produce large quantities of proinflammatory cytokines and cytotoxic mediators; thus, they have been implicated in the pathogenesis of many chronic inflammatory diseases. Recently, an increasing body of evidence has suggested that senescent T cells also have pathogenic potential in cardiovascular diseases, such as hypertension, atherosclerosis, and myocardial infarction, underscoring the detrimental roles of these cells in various chronic inflammatory responses. Given that cardiovascular disease is the number one cause of death worldwide, there is great interest in understanding the contribution of age-related immunological changes to its pathogenesis. In this review, we discuss general features of age-related alterations in T cell immunity and the possible roles of senescent T cells in the pathogenesis of cardiovascular disease
Publisher
SPRINGER-VERLAG ITALIA SRL
Issue Date
2016-08
Language
English
Article Type
Review
Keywords

CORONARY-ARTERY-DISEASE; CYTOMEGALOVIRUS-INFECTION; UNSTABLE ANGINA; IMMUNE-SYSTEM; ELDERLY INDIVIDUALS; ENDOTHELIAL-CELLS; UNITED-STATES; ATHEROSCLEROSIS; HYPERTENSION; IMMUNOSENESCENCE

Citation

CLINICAL AND EXPERIMENTAL MEDICINE, v.16, no.3, pp.257 - 263

ISSN
1591-8890
DOI
10.1007/s10238-015-0376-z
URI
http://hdl.handle.net/10203/213027
Appears in Collection
MSE-Journal Papers(저널논문)
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