Gene Regulation by MAPK Substrate Competition

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Developing tissues are patterned by coordinated activities of signaling systems, which can be integrated by a regulatory region of a gene that binds multiple transcription factors or by a transcription factor that is modified by multiple enzymes. Based on a combination of genetic and imaging experiments in the early Drosophila embryo, we describe a signal integration mechanism that cannot be reduced to a single gene regulatory element or a single transcription factor. This mechanism relies on an enzymatic network formed by mitogen-activated protein kinase (MAPK) and its substrates. Specifically, anteriorly localized MAPK substrates, such as Bicoid, antagonize MAPK-dependent down-regulation of Capicua, a repressor that is involved in gene regulation along the dorsoventral axis of the embryo. MAPK substrate competition provides a basis for ternary interaction of the anterior, dorsoventral, and terminal patterning systems. A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities.
Publisher
CELL PRESS
Issue Date
2011-06
Language
English
Article Type
Article
Keywords

DROSOPHILA-EMBRYO; DORSAL MORPHOGEN; SIGNALING SPECIFICITY; TERMINAL SYSTEM; DOWN-REGULATION; TORSO; EXPRESSION; PROTEIN; PATTERN; CAPICUA

Citation

DEVELOPMENTAL CELL, v.20, no.6, pp.880 - 887

ISSN
1534-5807
DOI
10.1016/j.devcel.2011.05.009
URI
http://hdl.handle.net/10203/211824
Appears in Collection
CBE-Journal Papers(저널논문)
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