DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Yong Fei | ko |
dc.contributor.author | He, Shan Shan | ko |
dc.contributor.author | Wang, Qiao Xiu | ko |
dc.contributor.author | Li, Fan | ko |
dc.contributor.author | Kwak, Mi Jeong | ko |
dc.contributor.author | Chen, Sally | ko |
dc.contributor.author | O’Connell, Douglas | ko |
dc.contributor.author | Zhang, Tian | ko |
dc.contributor.author | Pirooz, Sara Dolatshahi | ko |
dc.contributor.author | Jeon, Yongheui | ko |
dc.contributor.author | Chimge, Nyam Osor | ko |
dc.contributor.author | Frenkel, Baruch | ko |
dc.contributor.author | Choi, Younho | ko |
dc.contributor.author | Aldrovandi, Grace M | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Yuan, Zeng Qiang | ko |
dc.contributor.author | Liang, Chengyu | ko |
dc.date.accessioned | 2016-07-06T04:22:50Z | - |
dc.date.available | 2016-07-06T04:22:50Z | - |
dc.date.created | 2016-05-31 | - |
dc.date.created | 2016-05-31 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | MOLECULAR CELL, v.62, no.4, pp.507 - 519 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10203/209519 | - |
dc.description.abstract | UV-induced DNA damage, a major risk factor for skin cancers, is primarily repaired by nucleotide excision repair (NER). UV radiation resistance-associated gene (UVRAG) is a tumor suppressor involved in autophagy. It was initially isolated as a cDNA partially complementing UV sensitivity in xeroderma pigmentosum (XP), but this was not explored further. Here we show that UVRAG plays an integral role in UV-induced DNA damage repair. It localizes to photolesions and associates with DDB1 to promote the assembly and activity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex, leading to efficient XPC recruitment and global genomic NER. UVRAG depletion decreased substrate handover to XPC and conferred UV-damage hypersensitivity. We confirmed the importance of UVRAG for UV-damage tolerance using a Drosophila model. Furthermore, increased UV-signature mutations in melanoma correlate with reduced expression of UVRAG. Our results identify UVRAG as a regulator of CRL4(DDB2)-mediated NER and suggest that its expression levels may influence melanoma predisposition. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | NUCLEOTIDE EXCISION-REPAIR | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | INDUCED UBIQUITYLATION | - |
dc.subject | CUTANEOUS MELANOMA | - |
dc.subject | PROTEIN | - |
dc.subject | COMPLEX | - |
dc.subject | XPC | - |
dc.subject | MUTATIONS | - |
dc.subject | CANCER | - |
dc.subject | RISK | - |
dc.title | Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase | - |
dc.type | Article | - |
dc.identifier.wosid | 000376445000006 | - |
dc.identifier.scopusid | 2-s2.0-84969244611 | - |
dc.type.rims | ART | - |
dc.citation.volume | 62 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 507 | - |
dc.citation.endingpage | 519 | - |
dc.citation.publicationname | MOLECULAR CELL | - |
dc.identifier.doi | 10.1016/j.molcel.2016.04.014 | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Yang, Yong Fei | - |
dc.contributor.nonIdAuthor | He, Shan Shan | - |
dc.contributor.nonIdAuthor | Wang, Qiao Xiu | - |
dc.contributor.nonIdAuthor | Li, Fan | - |
dc.contributor.nonIdAuthor | Chen, Sally | - |
dc.contributor.nonIdAuthor | O’Connell, Douglas | - |
dc.contributor.nonIdAuthor | Zhang, Tian | - |
dc.contributor.nonIdAuthor | Pirooz, Sara Dolatshahi | - |
dc.contributor.nonIdAuthor | Jeon, Yongheui | - |
dc.contributor.nonIdAuthor | Chimge, Nyam Osor | - |
dc.contributor.nonIdAuthor | Frenkel, Baruch | - |
dc.contributor.nonIdAuthor | Choi, Younho | - |
dc.contributor.nonIdAuthor | Aldrovandi, Grace M | - |
dc.contributor.nonIdAuthor | Yuan, Zeng Qiang | - |
dc.contributor.nonIdAuthor | Liang, Chengyu | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCISION-REPAIR | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | INDUCED UBIQUITYLATION | - |
dc.subject.keywordPlus | CUTANEOUS MELANOMA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | XPC | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RISK | - |
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