Nanoparticles for Use in Enzyme Assays

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Nanoparticles (NPs) have created new ways to enhance the performance of classical biosensors in analytical sciences. NPs with unprecedented physiochemical properties can serve both as excellent carriers of bioreceptors and as signal enhancers, leading to improved assay platforms with high sensitivity and selectivity. Because enzymes play central roles in many cellular functions, specific and precise assays of their functions are of great significance in medical science and biotechnology. Here we review recent advances in NP-based biosensors and their use in enzyme assays. With fast and specific responses to enzyme-mediated reactions, NPs transduce and amplify the initial responses into various types of signals, such as electrochemical, optical and magnetic ones. Translation of their potential should lead to functionalized NPs finding wide applications in diagnostics, drug development and biotechnology.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2016-02
Language
English
Article Type
Review
Keywords

RESONANCE ENERGY-TRANSFER; CONJUGATED GOLD NANOPARTICLES; ENHANCED RAMAN-SPECTROSCOPY; SENSITIVE ELECTROCHEMICAL DETECTION; MATRIX-METALLOPROTEINASE ACTIVITY; PROTEIN-KINASE ACTIVITY; QUANTUM-DOT; COLORIMETRIC ASSAY; MAGNETIC NANOPARTICLES; SIGNAL AMPLIFICATION

Citation

CHEMBIOCHEM, v.17, no.4, pp.275 - 282

ISSN
1439-4227
DOI
10.1002/cbic.201500512
URI
http://hdl.handle.net/10203/207968
Appears in Collection
BS-Journal Papers(저널논문)
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