In vivo quantitation of injected circulating tumor cells from great saphenous vein based on video-rate confocal microscopy

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The number of circulating tumor cell (CTC) in the peripheral blood of cancer patients can be a valuable biomarker for cancer diagnosis and treatment monitoring. In this study, we implemented a custom-design video-rate confocal microscopy system in capable of direct visualization of fast flowing CTC at great saphenous vein (GSV) of a live animal model in vivo. Continuous acquisition of video-rate images at GSV revealed the highly dynamic time-dependent changes in the number of intravenously injected circulating tumor cells. By extracting a calibration factor through the hemocytometric analysis of intravenously injected long-circulating red blood cells, we established a novel quantitation method for CTC in whole body blood in vivo.
Publisher
OPTICAL SOC AMER
Issue Date
2015-06
Language
English
Article Type
Article
Citation

BIOMEDICAL OPTICS EXPRESS, v.6, no.6, pp.2158 - 2167

ISSN
2156-7085
DOI
10.1364/BOE.6.002158
URI
http://hdl.handle.net/10203/200242
Appears in Collection
NT-Journal Papers(저널논문)
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