Development of surface modification method and drug delivery system using nature-inspired adhesive biomaterials based on organic solvents유기용매 기반의 자연모사 접착성 소재를 이용한 표면 개질 및 약물 전달 기법 개발

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Polydopamine (pDA/PDA) coating has been widely utilized for a material-independent surface functionalization in many fields of science and engineering. However, the traditional pDA coating methods require the use of alkaline aqueous solutions, restricting a category of molecules that should be soluble in water. Here, we report that a method to form pDA coating and prepare PDA nanoparticles in organic solvents. In chapter 1, we demonstrate a one-step, organic solution-based surface chemistry that any type of material surface utilizing pDA coating. The pDA coating in methanol shows unexpectedly fast kinetics in surface modification resulting in ~ 50 nm in thickness for 4 hrs. Furthermore, it enables the surface functionalization of water-insoluble molecules such as anti-cancer drug, paclitaxel and alkanethiols that is previously difficult to achieve by the widely known pDA coating method. Simple one-step immersion of surfaces in a one-pot mixture of a water-insoluble molecule, dopamine, and piperidine results in the aforementioned results. Piperidine is utilized as an organic base which deprotonates/oxidizes dopamine molecules for the formation of the pDA, and we found that the pDA coating in organic solvents is effective only to polar protic solvents such as alcohols. Considering a variety of pDA applications, we anticipate that the pDA coating in organic solvents method might provide a new standard strategy of surface modifications for hydrolysable or degradable substrates as well as of immobilization of water-insoluble, functional molecules. In chapter 2, methods for general preparation of water-insoluble drugs encapsulation using mussel-inspired polydopamine (PDA) is demonstrated. Various approaches to increase the solubility of water-insoluble anti-cancer drugs in aqueous formulations have been undertaken with the aim of treating solid tumors through intravenous drug administration. Nanoscale drug carriers are particularly attractive for cancer therapy be...
Advisors
Lee, Hae-Shinresearcher이해신
Description
한국과학기술원 : 화학과,
Publisher
한국과학기술원
Issue Date
2014
Identifier
592512/325007  / 020124533
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 2014.8, [ viii, 47 p. ]

Keywords

Polydopamine; 약물 전달 시스템; 표면개질; 불수용성 물질; 유기용매; 폴리도파민; Organic Solvents; Water-insoluble Molecules; One-step Coating; Surface Functionalization; One-step Encapsulation; Nanoparticles; Tamoxifen; Drug Delivery Systems

URI
http://hdl.handle.net/10203/196436
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=592512&flag=dissertation
Appears in Collection
CH-Theses_Master(석사논문)
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