Identification of the DNA sequence interacting with Kaposis sarcoma-associated herpesvirus viral interferon regulatory factor 1

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal transduction. The amino-terminal region of vIRF1 displays significant homology to the DNA-binding domain of cellular interferon regulatory factors, supporting the theory that the protein interacts with specific DNA sequences. Here, we identify the consensus sequence of vIRF1-bindinh sites from a pool of random oligonucleotides. Moreover, our data show that vIRF1 interacts with the K3:viral dihydrofolate reductase:viral interleukin 6 promoter region in the KSHV genome.
Publisher
AMER SOC MICROBIOLOGY
Issue Date
2007-11
Language
ENG
Keywords

CELL-DEATH; TRANSCRIPTION; INHIBITION; REPRESSES; PATHWAY; PROTEIN; BINDS; P300; BETA; P53

Citation

JOURNAL OF VIROLOGY, v.81, no.22, pp.12680 - 12684

ISSN
0022-538X
DOI
10.1128/JVI.00556-07
URI
http://hdl.handle.net/10203/19081
Appears in Collection
BS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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