p-Sulfonatocalix[4]arene as a carrier for curcumin

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The encapsulation of curcumin using p-sulfonatocalix[4]arene (p-SC4) is an attempt to increase the bioavailability of curcumin by increasing water solubility. The degradation of curcumin due to the basicity of p-SC4 is circumvented by maintaining the pH at 3 using 2% hydrochloric acid. The interaction is studied using UV-visible absorption, emission, transient absorption and excited state lifetime methods. The encapsulation of curcumin with p-SC4 increases the excited lifetime of curcumin, as well as the lifetime of the transients (triplet state of curcumin and phenoxyl radical of curcumin) produced upon irradiation. The mode of interaction is studied using H-1 NMR and ROESY spectral techniques. The stability of curcumin in the presence of p-SC4 and the 2 : 1 ratio of p-SC4 binding with curcumin is established using HR-MS and MALDI-TOF analysis. The amount of enhancement in solubility is studied using the HTLC technique.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2014
Language
English
Article Type
Article
Keywords

POTENTIAL ANTICANCER AGENTS; ANTIPROLIFERATIVE ACTIVITY; RECOGNITION; INCLUSION; DESIGN; CANCER; ARENE; SULFONATOCALIXARENE; STABILIZATION; ENCAPSULATION

Citation

NEW JOURNAL OF CHEMISTRY, v.38, no.3, pp.1336 - 1345

ISSN
1144-0546
DOI
10.1039/c3nj00935a
URI
http://hdl.handle.net/10203/188819
Appears in Collection
CBE-Journal Papers(저널논문)
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