DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jee Seon | ko |
dc.contributor.author | Oh, Mi Hwa | ko |
dc.contributor.author | Park, Jae Yoon | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.contributor.author | Nam, YoonSung | ko |
dc.date.accessioned | 2013-08-08T05:43:09Z | - |
dc.date.available | 2013-08-08T05:43:09Z | - |
dc.date.created | 2013-03-25 | - |
dc.date.created | 2013-03-25 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.citation | BIOMATERIALS, v.34, no.9, pp.2370 - 2379 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/174521 | - |
dc.description.abstract | Small interfering RNA (siRNA) has been considered as a very attractive therapeutic alternative to chemical drugs; however, the chemical and biological instability and poor delivery efficiency of siRNA limit its success in clinical applications. Here we report a protein-resistant, reductively dissociable siRNA delivery system based on self-assembled polyelectrolyte complexes of dextran-siRNA conjugates linked by disulfide bonds. The prepared polyplexes exhibit excellent dispersion stability in the presence of serum because of the anti-fouling property of dextran exposed onto the complex surface. The enzymatic degradation of siRNA is also effectively suppressed within the complex. Folates are introduced as an active tumor-targeting moiety via the conjugation of folates to the hydroxyl groups of dextran. An in vivo investigation with a xenograft tumor mouse model shows that the folate-decorated dextran-siRNA conjugates are very efficiently targeted to cancer cells and induce sequence-specific gene silencing. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | GENE-THERAPY | - |
dc.subject | RNA INTERFERENCE | - |
dc.subject | DEXTRAN | - |
dc.subject | THERAPEUTICS | - |
dc.subject | CONJUGATE | - |
dc.subject | ACID | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MOLECULES | - |
dc.subject | PROSPECTS | - |
dc.subject | ARGININE | - |
dc.title | Protein-resistant, reductively dissociable polyplexes for in vivo systemic delivery and tumor-targeting of siRNA | - |
dc.type | Article | - |
dc.identifier.wosid | 000315179200022 | - |
dc.identifier.scopusid | 2-s2.0-84872372834 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 2370 | - |
dc.citation.endingpage | 2379 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.identifier.doi | 10.1016/j.biomaterials.2012.12.004 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.localauthor | Nam, YoonSung | - |
dc.contributor.nonIdAuthor | Kim, Jee Seon | - |
dc.contributor.nonIdAuthor | Oh, Mi Hwa | - |
dc.contributor.nonIdAuthor | Park, Jae Yoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | siRNA | - |
dc.subject.keywordAuthor | Dextran | - |
dc.subject.keywordAuthor | Polyethylenimine | - |
dc.subject.keywordAuthor | Biodegradation | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | Folate | - |
dc.subject.keywordPlus | GENE-THERAPY | - |
dc.subject.keywordPlus | RNA INTERFERENCE | - |
dc.subject.keywordPlus | DEXTRAN | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | CONJUGATE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | PROSPECTS | - |
dc.subject.keywordPlus | ARGININE | - |
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