This paper presents a novel optimum technique for optimum mix-proportion using database-based prediction model of material properties for an object function or a constraint condition. The proposed technique provides high reliability of results introducing effective region model, which assesses whether the prediction model is effective or not, in optimization process. In order to validate the proposed technique, a genetic algorithm was adopted as a optimum technique, and an artificial neural network was adopted as a prediction model for material properties and as a model for assessing effective region. The mix-proportion obtained from the proposed technique is more reasonable than that obtained from a general optimum technique.