DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, JW | ko |
dc.contributor.author | Yoon, C | ko |
dc.contributor.author | Piccoli, G | ko |
dc.contributor.author | Chung, HS | ko |
dc.contributor.author | Kim, K | ko |
dc.contributor.author | Lee, JR | ko |
dc.contributor.author | Lee, HW | ko |
dc.contributor.author | Kim, H | ko |
dc.contributor.author | Sala, C | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2007-09-19T02:56:58Z | - |
dc.date.available | 2007-09-19T02:56:58Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE, v.26, no.3, pp.963 - 970 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10203/1484 | - |
dc.description.abstract | Presynaptic active zones contain a cytoskeletal matrix called the CAZ, which is thought to play a critical role in the regulation of active zone formation and neurotransmitter release. Recent studies have identified several CAZ components, but little is known about how they contribute to the molecular organization of active zones. Here, we report a novel PDZ [ postsynaptic density-95/Discs large/zona occludens-1] interaction between the CAZ protein ERC2/CAST1 and the tandem PDZ protein syntenin-1, which is known to associate with diverse synaptic proteins, including glutamate receptor subunits, SynCAM, and beta-neurexin. This interaction promotes the localization of syntenin-1 at presynaptic ERC2 clusters. In addition to the PDZ interaction, multimerization of both ERC2 and syntenin-1 mediates syntenin-1 clustering. These results suggest that ERC2 promotes presynaptic syntenin-1 clustering by two distinct mechanisms and that syntenin-1 may contribute to the molecular organization of active zones by linking ERC2 and other CAZ components to diverse syntenin-1-associated synaptic proteins. | - |
dc.description.sponsorship | This work was supported by the National Creative Research Initiative Program of the Korean Ministry of Science and Technology (E.K.), the Giovanni Armenise-Harvard Foundation Career Development Program and European Community (LSHM-CT-2004-511995, SYNSCAFF to C.S.), and the 21st Century Frontier Research and Development Program in Neuroscience of the Korean Ministry of Science and Technology (M103KV010018-03K2201-01820 to H.K.). Correspondence should be addressed to Dr. Eunjoon Kim, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | SOC NEUROSCIENCE | - |
dc.subject | RIM-BINDING PROTEINS | - |
dc.subject | LIPRIN-ALPHA | - |
dc.subject | DIFFERENTIAL REGULATION | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | CYTOMATRIX | - |
dc.subject | SYNAPSES | - |
dc.subject | FAMILY | - |
dc.subject | CAST | - |
dc.subject | ASSOCIATION | - |
dc.subject | TERMINALS | - |
dc.title | Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin | - |
dc.type | Article | - |
dc.identifier.wosid | 000234715000027 | - |
dc.identifier.scopusid | 2-s2.0-32544447532 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 963 | - |
dc.citation.endingpage | 970 | - |
dc.citation.publicationname | JOURNAL OF NEUROSCIENCE | - |
dc.identifier.doi | 10.1523/JNEUROSCI.4475-05.2006 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Ko, JW | - |
dc.contributor.nonIdAuthor | Yoon, C | - |
dc.contributor.nonIdAuthor | Piccoli, G | - |
dc.contributor.nonIdAuthor | Chung, HS | - |
dc.contributor.nonIdAuthor | Kim, K | - |
dc.contributor.nonIdAuthor | Lee, JR | - |
dc.contributor.nonIdAuthor | Lee, HW | - |
dc.contributor.nonIdAuthor | Kim, H | - |
dc.contributor.nonIdAuthor | Sala, C | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | ERC | - |
dc.subject.keywordAuthor | CAST | - |
dc.subject.keywordAuthor | syntenin | - |
dc.subject.keywordAuthor | PDZ | - |
dc.subject.keywordAuthor | multimerization | - |
dc.subject.keywordAuthor | presynaptic regulation | - |
dc.subject.keywordPlus | RIM-BINDING PROTEINS | - |
dc.subject.keywordPlus | LIPRIN-ALPHA | - |
dc.subject.keywordPlus | DIFFERENTIAL REGULATION | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | CYTOMATRIX | - |
dc.subject.keywordPlus | SYNAPSES | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | CAST | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | TERMINALS | - |
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