Molecular design of functional polymers for gene therapy

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In the post genomic era, massive genetic information of the human being accelerates the identification of target genes for treating various diseases. A wide range of nucleic acid therapeutics have recently emerged as powerful new drug entities for treatment of gene-related diseases and for lead validation in the drug discovery process. The absence of an efficient delivery system for genetic drugs has been identified as a major hurdle for clinical applications. Various bio-mimicking polymers have been considered as potential nonviral carriers for gene therapy due to their safety in clinical use, despite their lower gene-transduction capacity compared to virus-based gene carriers that hold risk of potential immunogenicity and endogenous virus recombination. Improving specificity toward target cells and intracellular gene-transferring efficiency will be a prerequisite for successful clinical application of polymeric gene carriers. Multifunctional polymeric gene delivery carriers should be rationally designed at the molecular level for effective human gene therapy. (C) 2007 Published by Elsevier Ltd.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
2007-11
Language
English
Article Type
Review
Keywords

POLYION COMPLEX MICELLES; WATER-SOLUBLE LIPOPOLYMER; INDUCED PHASE-SEPARATION; POLY(2-(DIMETHYLAMINO)ETHYL METHACRYLATE)-BASED POLYPLEXES; OLIGONUCLEOTIDE-POLYETHYLENIMINE COMPLEXES; DNA/TRANSFERRIN-PEI COMPLEXES; FOLATE-GRAFT-POLYETHYLENIMINE; TISSUE ENGINEERING SCAFFOLDS; CHITOSAN-DNA NANOPARTICLES; MURINE CARDIAC TRANSPLANTS

Citation

PROGRESS IN POLYMER SCIENCE, v.32, no.11, pp.1239 - 1274

ISSN
0079-6700
DOI
10.1016/j.progpolymsci.2007.05.019
URI
http://hdl.handle.net/10203/13116
Appears in Collection
BS-Journal Papers(저널논문)
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