DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mok, Hyejung | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-11T01:57:45Z | - |
dc.date.available | 2009-11-11T01:57:45Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-09 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.70, no.1, pp.137 - 144 | - |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | http://hdl.handle.net/10203/12395 | - |
dc.description.abstract | Poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles encapsulating therapeutic proteins were prepared under a water-free formulation condition. Bovine serum albumin (BSA) and recombinant human growth hormone (rhGH) were homogeneously solubilized as nano-scale complexes in methylene chloride phase by using polyethylene glycol (PEG) as a complex-forming agent. The organic phase containing dissolved PLGA and PEG/protein complexes was directly spray dried to obtain PLGA microparticles encapsulating proteins. They exhibited sustained release profiles of BSA and rhGH up to 30 days with reduced initial bursts. The released protein molecules from the microparticles maintained structural integrity without aggregation, suggesting that the current single-step protein microencapsulation method without using water could be potentially applied for sustained delivery of a wide range of therapeutic protein drugs that are not soluble in organic solvents. (c) 2008 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | National Research Laboratory project and from the Ministry of Science and Technology, Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | HUMAN GROWTH-HORMONE | - |
dc.subject | BIODEGRADABLE MICROSPHERES | - |
dc.subject | SUSTAINED-RELEASE | - |
dc.subject | POLY(ETHYLENE GLYCOL) | - |
dc.subject | ACID) MICROSPHERES | - |
dc.subject | GENE DELIVERY | - |
dc.subject | ENCAPSULATION | - |
dc.subject | STABILITY | - |
dc.subject | PRECIPITATION | - |
dc.subject | DEGRADATION | - |
dc.title | Water-free microencapsulation of proteins within PLGA microparticles by spray drying using PEG-assisted protein solubilization technique in organic solvent | - |
dc.type | Article | - |
dc.identifier.wosid | 000259742600015 | - |
dc.identifier.scopusid | 2-s2.0-50149117923 | - |
dc.type.rims | ART | - |
dc.citation.volume | 70 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 137 | - |
dc.citation.endingpage | 144 | - |
dc.citation.publicationname | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.identifier.doi | 10.1016/j.ejpb.2008.04.006 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Mok, Hyejung | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | poly(D,L-lactic-co-glycolic acid) (PLGA) | - |
dc.subject.keywordAuthor | microparticles | - |
dc.subject.keywordAuthor | protein | - |
dc.subject.keywordAuthor | spray drying | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordPlus | HUMAN GROWTH-HORMONE | - |
dc.subject.keywordPlus | BIODEGRADABLE MICROSPHERES | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | ACID) MICROSPHERES | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | PRECIPITATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.