DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Seong | ko |
dc.contributor.author | Kim, Yeon-Jung | ko |
dc.contributor.author | Kim, Che-Lin | ko |
dc.contributor.author | Lee, Gyun-Min | ko |
dc.date.accessioned | 2013-03-12T23:55:33Z | - |
dc.date.available | 2013-03-12T23:55:33Z | - |
dc.date.created | 2012-08-10 | - |
dc.date.created | 2012-08-10 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | JOURNAL OF BIOTECHNOLOGY, v.161, no.1, pp.34 - 41 | - |
dc.identifier.issn | 0168-1656 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103933 | - |
dc.description.abstract | Previous research showed that co-down-regulation of caspase-3/7 in rCHO cells, unlike Bcl-2 overexpression, did not effectively block apoptotic cell death induced by 3 mM sodium butyrate (NaBu). Here, it is found that the control of autophagy is also related to this different response to NaBu treatment. With NaBu treatment, co-down-regulation of caspase-3/7 enhanced autophagy induction, whereas Bcl-2 overexpression delayed onset of autophagy induction in a Beclin-1 independent manner. The blockage of autophagy showed a detrimental effect on cell viability even in the Bcl-2 overexpressing cells, which suggests the importance of autophagy control for successful anti-cell death engineering of rCHO cells. (C) 2012 Published by Elsevier B.V. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | HAMSTER OVARY CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | DEATH | - |
dc.subject | CULTURE | - |
dc.subject | THROMBOPOIETIN | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | CROSSTALK | - |
dc.subject | PROTEINS | - |
dc.subject | CLEAVAGE | - |
dc.subject | SURVIVAL | - |
dc.title | Differential induction of autophagy in caspase-3/7 down-regulating and Bcl-2 overexpressing recombinant CHO cells subjected to sodium butyrate treatment | - |
dc.type | Article | - |
dc.identifier.wosid | 000306662800005 | - |
dc.identifier.scopusid | 2-s2.0-84863523132 | - |
dc.type.rims | ART | - |
dc.citation.volume | 161 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 34 | - |
dc.citation.endingpage | 41 | - |
dc.citation.publicationname | JOURNAL OF BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1016/j.jbiotec.2012.05.011 | - |
dc.contributor.localauthor | Lee, Gyun-Min | - |
dc.contributor.nonIdAuthor | Kim, Yeon-Jung | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Caspase-3/7 | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | Sodium butyrate | - |
dc.subject.keywordAuthor | CHO cells | - |
dc.subject.keywordAuthor | Beclin-1 | - |
dc.subject.keywordPlus | HAMSTER OVARY CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | THROMBOPOIETIN | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | CROSSTALK | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | SURVIVAL | - |
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