DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Seung_Wook | ko |
dc.contributor.author | Choi, Kyungsun | ko |
dc.contributor.author | Yoon, Jonghee | ko |
dc.contributor.author | Kim, Sunchang | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.date.accessioned | 2013-03-12T19:05:49Z | - |
dc.date.available | 2013-03-12T19:05:49Z | - |
dc.date.created | 2012-07-26 | - |
dc.date.created | 2012-07-26 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | JOURNAL OF CELLULAR PHYSIOLOGY, v.227, no.8, pp.3027 - 3035 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103226 | - |
dc.description.abstract | Bcl-2/adenovirus E1B 19-kDa interacting protein 1 (BNIP1), which is predominantly localized to the endoplasmic reticulum (ER), is a pro-apoptotic Bcl-2 homology domain 3 (BH3)-only protein. Here, we show that the expression of BNIP1 induced not only a highly interconnected ER network but also mitochondrial fragmentation in a BH3 domain-dependent manner. Functional analysis demonstrated that BNIP1 expression increased dynamin-related protein 1 (Drp1) expression followed by the mitochondrial translocation of Drp1 and subsequent mitochondrial fission. Both BNIP1-induced mitochondrial fission and the translocation of Drp1 were abrogated by Bcl-2 overexpression. These results collectively indicate that ER-specific BNIP1 plays an important role in mitochondrial dynamics by modulating the mitochondrial fission protein Drp1 in a BH3 domain-dependent fashion. J. Cell. Physiol. 227: 30273035, 2012. (c) 2011 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | CYTOCHROME-C RELEASE | - |
dc.subject | CELL-DEATH | - |
dc.subject | APOPTOSIS | - |
dc.subject | DRP1 | - |
dc.subject | MORPHOLOGY | - |
dc.subject | FISSION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | FUSION | - |
dc.subject | FAMILY | - |
dc.subject | DYNAMICS | - |
dc.title | Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2- and Drp1-dependent manner | - |
dc.type | Article | - |
dc.identifier.wosid | 000303391000008 | - |
dc.identifier.scopusid | 2-s2.0-84860431569 | - |
dc.type.rims | ART | - |
dc.citation.volume | 227 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 3027 | - |
dc.citation.endingpage | 3035 | - |
dc.citation.publicationname | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.identifier.doi | 10.1002/jcp.23044 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Sunchang | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Choi, Kyungsun | - |
dc.contributor.nonIdAuthor | Yoon, Jonghee | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CYTOCHROME-C RELEASE | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DRP1 | - |
dc.subject.keywordPlus | MORPHOLOGY | - |
dc.subject.keywordPlus | FISSION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | DYNAMICS | - |
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