DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Seunghee | ko |
dc.contributor.author | Kim, Jinhee | ko |
dc.contributor.author | Seo, Ju Hyeon | ko |
dc.contributor.author | Jung, Kyung Hee | ko |
dc.contributor.author | Hong, Soon-Sun | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.date.accessioned | 2013-03-12T12:36:35Z | - |
dc.date.available | 2013-03-12T12:36:35Z | - |
dc.date.created | 2012-08-14 | - |
dc.date.created | 2012-08-14 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | JOURNAL OF MEDICINAL CHEMISTRY, v.55, no.11, pp.5337 - 5349 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10203/102345 | - |
dc.description.abstract | Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. In this study, we designed and synthesized a series of novel 7-azaindole-based Trk kinase inhibitors through the structure-based design strategy. By varying the functional groups at the 3 and 5 positions of a 7-azaindole scaffold, we studied the structure-activity relationships (SAR) profiles and identified a series of potent Trk inhibitors. Representative derivatives showed desirable activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | NERVE GROWTH-FACTOR | - |
dc.subject | KINASE INHIBITORS | - |
dc.subject | BREAST-CANCER | - |
dc.subject | IDENTIFICATION | - |
dc.subject | METASTASIS | - |
dc.subject | DISCOVERY | - |
dc.subject | CELLS | - |
dc.title | Design, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities | - |
dc.type | Article | - |
dc.identifier.wosid | 000305356400033 | - |
dc.identifier.scopusid | 2-s2.0-84862280700 | - |
dc.type.rims | ART | - |
dc.citation.volume | 55 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 5337 | - |
dc.citation.endingpage | 5349 | - |
dc.citation.publicationname | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.identifier.doi | 10.1021/jm3002982 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Seo, Ju Hyeon | - |
dc.contributor.nonIdAuthor | Jung, Kyung Hee | - |
dc.contributor.nonIdAuthor | Hong, Soon-Sun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | KINASE INHIBITORS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | CELLS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.