DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kataru, Raghu Prasad | ko |
dc.contributor.author | Kim, Hon-Soul | ko |
dc.contributor.author | Jang, Chol-Soon | ko |
dc.contributor.author | Choi, Dong-Kyu | ko |
dc.contributor.author | Koh, Bong-Ihn | ko |
dc.contributor.author | Kim, Min-Ah | ko |
dc.contributor.author | Gollamudi, Sudheer | ko |
dc.contributor.author | Kim, Yun-Keun | ko |
dc.contributor.author | Lee, Seung-Hyo | ko |
dc.contributor.author | Koh, Gou-Young | ko |
dc.date.accessioned | 2013-03-12T03:47:41Z | - |
dc.date.available | 2013-03-12T03:47:41Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | IMMUNITY, v.34, no.1, pp.96 - 107 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101244 | - |
dc.description.abstract | Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelial growth factors secreted by B cells, macrophages, and dendritic cells (DCs). Here, we show that LNLV formation was negatively regulated by T cells. In both steady and inflammatory states, the density of LNLVs was increased in the absence of T cells but decreased when T cells were restored. Interferon-gamma secretion by T cells suppressed lymphatic-specific genes in lymphatic endothelial cells and consequently caused marked reduction in LNLV formation. When T cells were depleted, recruitment of antigen-carrying DCs to LNs was augmented, reflecting a compensatory mechanism for antigen presentation to T cells through increased LNLVs. Thus, T cells maintain the homeostatic balance of LNLV density through a negative paracrine action of interferon-gamma. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | IFN-GAMMA | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | INDUCED LYMPHANGIOGENESIS | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | INFLAMMATION | - |
dc.subject | MECHANISMS | - |
dc.subject | SYSTEM | - |
dc.subject | VEGF | - |
dc.subject | VASCULATURE | - |
dc.title | T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation | - |
dc.type | Article | - |
dc.identifier.wosid | 000287336600013 | - |
dc.identifier.scopusid | 2-s2.0-78751688024 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 96 | - |
dc.citation.endingpage | 107 | - |
dc.citation.publicationname | IMMUNITY | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Seung-Hyo | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.nonIdAuthor | Jang, Chol-Soon | - |
dc.contributor.nonIdAuthor | Koh, Bong-Ihn | - |
dc.contributor.nonIdAuthor | Kim, Yun-Keun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | INDUCED LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | VASCULATURE | - |
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