DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Shin-Hae | ko |
dc.contributor.author | Choi, Si-Sun | ko |
dc.contributor.author | Kim, Yoon Jung | ko |
dc.contributor.author | Chang, YongKeun | ko |
dc.contributor.author | Sherman, David H. | ko |
dc.contributor.author | Kim, Eung-Soo | ko |
dc.date.accessioned | 2013-03-12T02:21:51Z | - |
dc.date.available | 2013-03-12T02:21:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-07 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.36, no.7, pp.993 - 998 | - |
dc.identifier.issn | 1367-5435 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101076 | - |
dc.description.abstract | Comparative transcriptome analysis has revealed several acidic pH shock-induced genes presumably involved with stimulation of antibiotic production by S. coelicolor (Kim et al. Appl Microbiol Biotechnol 2007). Streptomyces sp. CK4412 produces a novel T cell-specific immunosuppressive compound, tautomycetin (TMC). When cultured at acidic pH medium, it also exhibited higher TMC productivity. To verify a gene responsible for acidic pH shock-induced TMC stimulation, a putative acid-shock-induced gene, SCO7832 encoding an Na(+)/H(+) antiporter protein, was cloned under the influence of a strong constitutive ermE* promoter in an integrative expression pSET152 vector. This was followed by its conjugation into the TMC-producing Streptomyces sp. CK4412. Comparing TMC production and antifungal activity of wild-type and the SCO7832-containing exconjugant revealed that SCO7832 stimulated TMC production more than 3.5-fold in Streptomyces sp. CK4412. The over-expression of SCO7832 did not affect the ratio between intra- and extra-cellular TMC productions. However, it significantly stimulated the expression of a TMC-specific positive regulatory gene. This implies that the stimulatory effect of SCO7832 functions in TMC-producing Streptomyces sp. CK4412 via up-regulation of a TMC pathway-specific positive regulatory gene, tmcN overexpression. | - |
dc.language | English | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | COELICOLOR A3(2) | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | PH SHOCK | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | ACTINORHODIN | - |
dc.subject | ANTIBIOTICS | - |
dc.subject | INDUCTION | - |
dc.subject | CELLS | - |
dc.subject | DNA | - |
dc.title | Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp CK4412 | - |
dc.type | Article | - |
dc.identifier.wosid | 000266924700015 | - |
dc.identifier.scopusid | 2-s2.0-67449132112 | - |
dc.type.rims | ART | - |
dc.citation.volume | 36 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 993 | - |
dc.citation.endingpage | 998 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1007/s10295-009-0580-5 | - |
dc.contributor.localauthor | Chang, YongKeun | - |
dc.contributor.nonIdAuthor | Park, Shin-Hae | - |
dc.contributor.nonIdAuthor | Choi, Si-Sun | - |
dc.contributor.nonIdAuthor | Sherman, David H. | - |
dc.contributor.nonIdAuthor | Kim, Eung-Soo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Antibiotic stimulation | - |
dc.subject.keywordAuthor | SCO7832 | - |
dc.subject.keywordAuthor | Tautomycetin | - |
dc.subject.keywordAuthor | Streptomyces | - |
dc.subject.keywordAuthor | pH-shock | - |
dc.subject.keywordPlus | COELICOLOR A3(2) | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | PH SHOCK | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | ACTINORHODIN | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DNA | - |
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