ISOLATION OF VINDOLINE FROM CATHARANTHUS-ROSEUS BY SUPERCRITICAL FLUID EXTRACTION

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Vindoline was extracted from the leaves of Catharanthus roseus over the ranges of 35-70-degrees-C and 100-300 bar using supercritical carbon dioxide with and without the addition of 3 wt % ethanol as a cosolvent. The vindoline contents in the extracts were determined by HPLC and identified by LC/MS. The remarkable highest vindoline concentration, 58 wt %, was obtained at the lowest temperature, 35-degrees-C, and the highest pressure, 300 bar, of this study. The use of a cosolvent only slightly improved the extraction yields or selectivities at some experimental conditions.
Publisher
AMER CHEMICAL SOC
Issue Date
1992-11
Language
ENG
Article Type
Note
Citation

BIOTECHNOLOGY PROGRESS, v.8, no.6, pp.583 - 586

ISSN
8756-7938
URI
http://hdl.handle.net/10203/10028
Appears in Collection
CBE-Journal Papers(저널논문)
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