DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tung, Thai Quang | ko |
dc.contributor.author | Lee, Doheon | ko |
dc.date.accessioned | 2013-03-11T17:39:32Z | - |
dc.date.available | 2013-03-11T17:39:32Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | BIOINFORMATICS, v.26, no.19, pp.2477 - 2479 | - |
dc.identifier.issn | 1367-4803 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99756 | - |
dc.description.abstract | Motivation: Mathematical models of biological systems often have a large number of parameters whose combinational variations can yield distinct qualitative behaviors. Since it is intractable to examine all possible combinations of parameters for non-trivial biological pathways, it is required to have a systematic strategy to explore the parameter space in a computational way so that dynamic behaviors of a given pathway are estimated. Results: We present PSExplorer, a computational tool for exploring qualitative behaviors and key parameters of molecular signaling pathways. Utilizing the Latin hypercube sampling and a clustering technique in a recursive paradigm, the software enables users to explore the whole parameter space of the models to search for robust qualitative behaviors. The parameter space is partitioned into sub-regions according to behavioral differences. Sub-regions showing robust behaviors can be identified for further analyses. The partitioning result presents a tree structure from which individual and combinational effects of parameters on model behaviors can be assessed and key factors of the models are readily identified. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | PSExplorer: whole parameter space exploration for molecular signaling pathway dynamics | - |
dc.type | Article | - |
dc.identifier.wosid | 000282170000024 | - |
dc.identifier.scopusid | 2-s2.0-77957225887 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.issue | 19 | - |
dc.citation.beginningpage | 2477 | - |
dc.citation.endingpage | 2479 | - |
dc.citation.publicationname | BIOINFORMATICS | - |
dc.identifier.doi | 10.1093/bioinformatics/btq440 | - |
dc.contributor.localauthor | Lee, Doheon | - |
dc.type.journalArticle | Article | - |
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