DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Han-Ki | ko |
dc.contributor.author | Yang, Yoosoo | ko |
dc.contributor.author | Su, Zengliu | ko |
dc.contributor.author | Hyeon, Changbong | ko |
dc.contributor.author | Lee, Tae-Sun | ko |
dc.contributor.author | Lee, Hong-Won | ko |
dc.contributor.author | Kweon, Dae-Hyuk | ko |
dc.contributor.author | Shin, Yeon-Kyun | ko |
dc.contributor.author | Yoon, Tae-Young | ko |
dc.date.accessioned | 2013-03-11T10:58:57Z | - |
dc.date.available | 2013-03-11T10:58:57Z | - |
dc.date.created | 2012-03-13 | - |
dc.date.created | 2012-03-13 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | SCIENCE, v.328, no.5979, pp.760 - 763 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/99086 | - |
dc.description.abstract | In neurons, synaptotagmin 1 (Syt1) is thought to mediate the fusion of synaptic vesicles with the plasma membrane when presynaptic Ca2+ levels rise. However, in vitro reconstitution experiments have failed to recapitulate key characteristics of Ca2+-triggered membrane fusion. Using an in vitro single-vesicle fusion assay, we found that membrane-anchored Syt1 enhanced Ca2+ sensitivity and fusion speed. This stimulatory activity of membrane-anchored Syt1 dropped as the Ca2+ level rose beyond physiological levels. Thus, Syt1 requires the membrane anchor to stimulate vesicle fusion at physiological Ca2+ levels and may function as a dynamic presynaptic Ca2+ sensor to control the probability of neurotransmitter release. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.subject | NEUROTRANSMITTER RELEASE | - |
dc.subject | PHOSPHOLIPIDS | - |
dc.subject | PENETRATION | - |
dc.subject | MACHINERY | - |
dc.subject | CALCIUM | - |
dc.subject | BINDING | - |
dc.subject | SNARES | - |
dc.subject | DOMAIN | - |
dc.subject | CA2+ | - |
dc.title | Dynamic Ca(2+)-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1 | - |
dc.type | Article | - |
dc.identifier.wosid | 000277357100042 | - |
dc.identifier.scopusid | 2-s2.0-77952231768 | - |
dc.type.rims | ART | - |
dc.citation.volume | 328 | - |
dc.citation.issue | 5979 | - |
dc.citation.beginningpage | 760 | - |
dc.citation.endingpage | 763 | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.1187722 | - |
dc.contributor.localauthor | Yoon, Tae-Young | - |
dc.contributor.nonIdAuthor | Lee, Han-Ki | - |
dc.contributor.nonIdAuthor | Yang, Yoosoo | - |
dc.contributor.nonIdAuthor | Su, Zengliu | - |
dc.contributor.nonIdAuthor | Hyeon, Changbong | - |
dc.contributor.nonIdAuthor | Kweon, Dae-Hyuk | - |
dc.contributor.nonIdAuthor | Shin, Yeon-Kyun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NEUROTRANSMITTER RELEASE | - |
dc.subject.keywordPlus | PHOSPHOLIPIDS | - |
dc.subject.keywordPlus | PENETRATION | - |
dc.subject.keywordPlus | MACHINERY | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SNARES | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | CA2+ | - |
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