Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing

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We report a quantitative phase microscope based on spectral domain optical coherence tomography and line-field illumination. The line illumination allows self phase-referencing method to reject common-mode phase noise. The quantitative phase microscope also features a separate reference arm, permitting the use of high numerical aperture (NA > 1) microscope objectives for high resolution phase measurement at multiple points along the line of illumination. We demonstrate that the path-length sensitivity of the instrument can be as good as 41 pm / root Hz, which makes it suitable for nanometer scale study of cell motility. We present the detection of natural motions of cell surface and two-dimensional surface profiling of a HeLa cell. (C) 2009 Optical Society of America
Publisher
OPTICAL SOC AMER
Issue Date
2009-06
Language
English
Article Type
Article
Citation

OPTICS EXPRESS, v.17, no.13, pp.10681 - 10687

ISSN
1094-4087
URI
http://hdl.handle.net/10203/99083
Appears in Collection
PH-Journal Papers(저널논문)
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