DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kang-Ho | ko |
dc.contributor.author | Choi, Suk-Hwan | ko |
dc.contributor.author | Lee, Jeong-Oen | ko |
dc.contributor.author | Sohn, Mi-Jin | ko |
dc.contributor.author | Yoon, Jun-Bo | ko |
dc.contributor.author | Cho, Gyu-Hyeong | ko |
dc.date.accessioned | 2013-03-11T08:33:31Z | - |
dc.date.available | 2013-03-11T08:33:31Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | BIOSENSORS BIOELECTRONICS, v.26, no.11, pp.4591 - 4595 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98807 | - |
dc.description.abstract | This paper describes a sensor for label-free, fully electrical detection of DNA hybridization based on capacitive changes in the electrode-electrolyte interface. The sensor measures capacitive changes in real time according to a charging-discharging principle that is limited by the hysteresis window. In addition, a novel autonomous searching technique, which exclusively monitors desorption-free hybridized electrodes among electrode arrays, enhances the performance of the sensor compared with conventional capacitive measurement. The sensor system achieves a detection range of 80 dB. The integrated circuit sensor is fabricated with a 0.35 mu m CMOS process. The proposed sensor offers rapid, robust and inexpensive measurement of capacitance with highly integrated detection circuitry. It also facilitates quantitative evaluations of molecular densities on a chip with distinctive impedance variations by monitoring desorption-free hybridized electrodes. Our electrical biosensor has great potential for use with bio analytical tools and point-of-care diagnosis. (C) 2011 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER ADVANCED TECHNOLOGY | - |
dc.subject | GOLD SURFACES | - |
dc.subject | IMMOBILIZATION | - |
dc.subject | BIOSENSORS | - |
dc.subject | PROBE | - |
dc.subject | ARRAY | - |
dc.subject | CHIP | - |
dc.title | An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization | - |
dc.type | Article | - |
dc.identifier.wosid | 000293104100053 | - |
dc.identifier.scopusid | 2-s2.0-79959218747 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 4591 | - |
dc.citation.endingpage | 4595 | - |
dc.citation.publicationname | BIOSENSORS BIOELECTRONICS | - |
dc.contributor.localauthor | Yoon, Jun-Bo | - |
dc.contributor.localauthor | Cho, Gyu-Hyeong | - |
dc.contributor.nonIdAuthor | Sohn, Mi-Jin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Capacitance | - |
dc.subject.keywordAuthor | DNA hybridization | - |
dc.subject.keywordAuthor | Desorption | - |
dc.subject.keywordAuthor | Impedance | - |
dc.subject.keywordAuthor | Sensor | - |
dc.subject.keywordPlus | GOLD SURFACES | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | BIOSENSORS | - |
dc.subject.keywordPlus | PROBE | - |
dc.subject.keywordPlus | ARRAY | - |
dc.subject.keywordPlus | CHIP | - |
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