DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ki-Bong | ko |
dc.contributor.author | Ha, Yong-Hwang | ko |
dc.contributor.author | Kaufman, Leo | ko |
dc.contributor.author | Churchill, David G | ko |
dc.date.accessioned | 2013-03-11T04:37:37Z | - |
dc.date.available | 2013-03-11T04:37:37Z | - |
dc.date.created | 2012-03-07 | - |
dc.date.created | 2012-03-07 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | INORGANIC CHEMISTRY, v.51, no.2, pp.928 - 938 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98266 | - |
dc.description.abstract | Herein, molecular fluorescence 'OFF-ON' behavior with aqueous addition of biological phosphate and Zn(2+) is studied with Zn(2)(slys)(2)Cl(2) [H(2)slys = 6-amino-2-{(2-hydroxybenzylidene)amino}hexanoic acid], a fluorescent water-soluble complex, using various spectroscopic tools (e.g., (31)P NMR, UV-vis, emission, and CD spectroscopy) at the micromolar level. Adduct-dependent fluorescence intensity changes can be interpreted as a two-input (cation/anion) implication molecular logic gating system. A displacement study of PPi from the dizinc complex is also reported. Diphosphate and triphosphate addition/displacements were also studied. (31)P NMR spectroscopy shows gradual NMR peak shifts from bound ADP/GDP to free ADP/GDP with increasing [PPi]. In the emission spectrum, fluorescence quenching is shown: CD signal maxima decrease with addition of PPi. These displacement events are also tested with triphosphates (ATP, GTP), and their binding strength/displacement ability over ADP/GDP is quantified: PPi > ATP approximate to GTP (3.35 +/- 0.77 X 10(4) M(-1) for PPi, 7.73 +/- 1.79 X 10(3) M(-1) for ATP, 9.21 +/- 2.88 X 10(3) M(-1) for GTP over 1.ADP). Many anions and cations were also screened for selectivity. Tubulin polymerization was assayed in the presence of 1 and its copper analogue which reflected a slight inhibition in polymerization. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | 100-PERCENT AQUEOUS-SOLUTION | - |
dc.subject | OFF-ON-OFF | - |
dc.subject | PHYSIOLOGICAL CONDITIONS | - |
dc.subject | FLUORESCENT SENSORS | - |
dc.subject | NUCLEOTIDE EXCHANGE | - |
dc.subject | SELECTIVE DETECTION | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | CHARGE-TRANSFER | - |
dc.subject | METAL-IONS | - |
dc.subject | PYROPHOSPHATE | - |
dc.title | Labile Zinc-Assisted Biological Phosphate Chemosensing and Related Molecular Logic Gating Interpretations | - |
dc.type | Article | - |
dc.identifier.wosid | 000299028800027 | - |
dc.identifier.scopusid | 2-s2.0-84862908707 | - |
dc.type.rims | ART | - |
dc.citation.volume | 51 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 928 | - |
dc.citation.endingpage | 938 | - |
dc.citation.publicationname | INORGANIC CHEMISTRY | - |
dc.identifier.doi | 10.1021/ic201948c | - |
dc.contributor.localauthor | Churchill, David G | - |
dc.contributor.nonIdAuthor | Kaufman, Leo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | 100-PERCENT AQUEOUS-SOLUTION | - |
dc.subject.keywordPlus | OFF-ON-OFF | - |
dc.subject.keywordPlus | PHYSIOLOGICAL CONDITIONS | - |
dc.subject.keywordPlus | FLUORESCENT SENSORS | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCHANGE | - |
dc.subject.keywordPlus | SELECTIVE DETECTION | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CHARGE-TRANSFER | - |
dc.subject.keywordPlus | METAL-IONS | - |
dc.subject.keywordPlus | PYROPHOSPHATE | - |
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