Sensitive and multiplexed analysis of aflatoxins using time-of-flight secondary ion mass spectrometry

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A rapid and reliable analysis of toxins is prerequisite for food control and human healthcare. Here we demonstrate a simple and multiplexed assay of aflatoxins using time-of-flight secondary ion mass spectrometry (TOF-SIMS). By simply adsorbing either a single analyte or mixed ones onto a gold substrate, the corresponding secondary molecular ions ([M+H](+)) were clearly observed in a single mass spectrum. As a result of concentration-dependent peak intensity, quantitative and multiplexed analysis of different aflatoxin analogs from corns was accomplished with immunoaffinity column and TOF-SIMS analysis, which showed a good correlation with HPLC data. The detection sensitivity was estimated to be as low as 10 ng mL(-1) This approach presented here will find a wide application to detection of low-levels of toxins in a rapid and multiplexed way.
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Issue Date
2012-03
Language
English
Article Type
Article
Keywords

SELF-ASSEMBLED MONOLAYERS; TOF-SIMS; QUANTITATIVE-ANALYSIS; SURFACE-ANALYSIS; B-1; PROTEIN; COLUMN; ELISA; HPLC; NANOPARTICLES

Citation

BIOCHIP JOURNAL, v.6, no.1, pp.34 - 40

ISSN
1976-0280
DOI
10.1007/s13206-012-6105-8
URI
http://hdl.handle.net/10203/98248
Appears in Collection
BS-Journal Papers(저널논문)
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