Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging

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We present herein a silver nanostructure-assisted sensing platform which consists of a combined structure of Ag nanowire (NW) and nanodot (ND) array. Highly enhanced fluorescence from fluorophore is attributed to a strongly coupled optical near-field interaction between proximately located Ag NW and NDs. We obtained enhanced fluorescence intensity with up to 140 folds, as contrasted from background intensity, reaching a theoretical maximum value. On the other hand, fluorescence lifetime was greatly reduced to 0.27 ns (from 2.17 ns for the same fluorophores without nanostructure). This novel platform can be a promising utility for optical imaging and labeling of biological systems with a great sensitivity. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3579157]
Publisher
SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
Issue Date
2011-05
Language
English
Article Type
Article
Keywords

SURFACE-ENHANCED FLUORESCENCE; ISLAND FILMS; RAMAN-SCATTERING; ANTIBODIES

Citation

JOURNAL OF BIOMEDICAL OPTICS, v.16, no.5

ISSN
1083-3668
URI
http://hdl.handle.net/10203/98182
Appears in Collection
CH-Journal Papers(저널논문)
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