DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyunseung | ko |
dc.contributor.author | Li, Guang-Yong | ko |
dc.contributor.author | Jeong, Yujeong | ko |
dc.contributor.author | Jung, Kyung Hee | ko |
dc.contributor.author | Lee, Ju-Hee | ko |
dc.contributor.author | Ham, Kyungrok | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.contributor.author | Hong, Soon-Sun | ko |
dc.date.accessioned | 2013-03-11T03:36:59Z | - |
dc.date.available | 2013-03-11T03:36:59Z | - |
dc.date.created | 2012-04-20 | - |
dc.date.created | 2012-04-20 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | CANCER LETTERS, v.318, no.1, pp.68 - 75 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10203/98162 | - |
dc.description.abstract | Potentiation of anti-breast cancer activity of an imidazopyridine-based PI3K alpha inhibitor, HS-104, was investigated in human breast cancer cells. HS-104 shows strong inhibitory activity against recombinant PI3K alpha isoform and the PI3K signaling pathway, resulting in anti-proliferative activity in breast cancer cells. It also induced cell cycle arrest at the G(2)/M phase as well as apoptosis. Furthermore, oral administration of HS-104 significantly inhibited the growth of tumor in SkBr3 mouse xenograft models. Therefore, HS-104 could be considered as a potential candidate for the treatment of human breast cancer. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | VIVO ANTITUMOR-ACTIVITY | - |
dc.subject | IN-VIVO | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | PATHWAY | - |
dc.subject | PTEN | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | MUTATIONS | - |
dc.subject | CARCINOMA | - |
dc.subject | SURVIVAL | - |
dc.subject | KINASE | - |
dc.title | A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000301624300009 | - |
dc.identifier.scopusid | 2-s2.0-84857140273 | - |
dc.type.rims | ART | - |
dc.citation.volume | 318 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 68 | - |
dc.citation.endingpage | 75 | - |
dc.citation.publicationname | CANCER LETTERS | - |
dc.identifier.doi | 10.1016/j.canlet.2011.12.001 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Lee, Hyunseung | - |
dc.contributor.nonIdAuthor | Li, Guang-Yong | - |
dc.contributor.nonIdAuthor | Jung, Kyung Hee | - |
dc.contributor.nonIdAuthor | Lee, Ju-Hee | - |
dc.contributor.nonIdAuthor | Ham, Kyungrok | - |
dc.contributor.nonIdAuthor | Hong, Soon-Sun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | PI3K | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordPlus | VIVO ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PTEN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | KINASE | - |
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