Development of a Point-of-Care Testing Platform With a Nanogap-Embedded Separated Double-Gate Field Effect Transistor Array and Its Readout System for Detection of Avian Influenza

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dc.contributor.authorIm, Mae-Soonko
dc.contributor.authorAhn, Jae-Hyukko
dc.contributor.authorHan, Jin-Wooko
dc.contributor.authorPark, Tae-Jungko
dc.contributor.authorLee, Sang-Yupko
dc.contributor.authorChoi, Yang-Kyuko
dc.date.accessioned2013-03-11T03:22:55Z-
dc.date.available2013-03-11T03:22:55Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2011-02-
dc.identifier.citationIEEE SENSORS JOURNAL, v.11, no.2, pp.351 - 360-
dc.identifier.issn1530-437X-
dc.identifier.urihttp://hdl.handle.net/10203/98135-
dc.description.abstractLabel-free electrical detection of avian influenza (AI) is demonstrated for the development of a point-of-care testing (POCT) platform. For a new POCT platform, a novel field effect transistor (FET)-based biosensor array was fabricated with conventional complementary metal-oxide-semiconductor (CMOS) technology. Nanogap-embedded separated double-gate FETs (nanogap-DGFETs) were realized in a 6 x 6 array as a biosensor cartridge. Moreover, the low-noise readout circuit was designed and fabricated using a 0.35-mu m standard CMOS process. The AI antigen and antibody were bound with the aid of silica-binding proteins (SBP) in the nanogap of the biosensor device. Because the gate dielectric constant was increased by the immobilized biomolecules, the threshold voltage of the nanogap-DGFET was reduced while the drain-to-source current was enhanced. Drain-to-source currents of the nanogap-DGFET array were successfully acquired using the fabricated readout circuitry and measurement setup. This platform is suitable for a simple and effective label-free detection of AI in POCT applications.-
dc.languageEnglish-
dc.publisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC-
dc.subjectBLOOD ANALYSIS-
dc.subjectANTIBODY-
dc.subjectVIRUS-
dc.subjectBIOSENSORS-
dc.subjectSENSORS-
dc.subjectPROTEIN-
dc.titleDevelopment of a Point-of-Care Testing Platform With a Nanogap-Embedded Separated Double-Gate Field Effect Transistor Array and Its Readout System for Detection of Avian Influenza-
dc.typeArticle-
dc.identifier.wosid000284364500012-
dc.identifier.scopusid2-s2.0-78649264150-
dc.type.rimsART-
dc.citation.volume11-
dc.citation.issue2-
dc.citation.beginningpage351-
dc.citation.endingpage360-
dc.citation.publicationnameIEEE SENSORS JOURNAL-
dc.identifier.doi10.1109/JSEN.2010.2062502-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Sang-Yup-
dc.contributor.localauthorChoi, Yang-Kyu-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorAvian influenza (AI)-
dc.subject.keywordAuthorbiosensor-
dc.subject.keywordAuthorfield-effect transistor (FET)-
dc.subject.keywordAuthornanogap-
dc.subject.keywordAuthorpoint-of-care testing (POCT)-
dc.subject.keywordAuthorsilica-binding proteins (SBP)-
dc.subject.keywordPlusBLOOD ANALYSIS-
dc.subject.keywordPlusANTIBODY-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordPlusBIOSENSORS-
dc.subject.keywordPlusSENSORS-
dc.subject.keywordPlusPROTEIN-
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