Development of a Point-of-Care Testing Platform With a Nanogap-Embedded Separated Double-Gate Field Effect Transistor Array and Its Readout System for Detection of Avian Influenza

Cited 35 time in webofscience Cited 0 time in scopus
  • Hit : 357
  • Download : 1
Label-free electrical detection of avian influenza (AI) is demonstrated for the development of a point-of-care testing (POCT) platform. For a new POCT platform, a novel field effect transistor (FET)-based biosensor array was fabricated with conventional complementary metal-oxide-semiconductor (CMOS) technology. Nanogap-embedded separated double-gate FETs (nanogap-DGFETs) were realized in a 6 x 6 array as a biosensor cartridge. Moreover, the low-noise readout circuit was designed and fabricated using a 0.35-mu m standard CMOS process. The AI antigen and antibody were bound with the aid of silica-binding proteins (SBP) in the nanogap of the biosensor device. Because the gate dielectric constant was increased by the immobilized biomolecules, the threshold voltage of the nanogap-DGFET was reduced while the drain-to-source current was enhanced. Drain-to-source currents of the nanogap-DGFET array were successfully acquired using the fabricated readout circuitry and measurement setup. This platform is suitable for a simple and effective label-free detection of AI in POCT applications.
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Issue Date
2011-02
Language
English
Article Type
Article
Keywords

BLOOD ANALYSIS; ANTIBODY; VIRUS; BIOSENSORS; SENSORS; PROTEIN

Citation

IEEE SENSORS JOURNAL, v.11, no.2, pp.351 - 360

ISSN
1530-437X
DOI
10.1109/JSEN.2010.2062502
URI
http://hdl.handle.net/10203/98135
Appears in Collection
CBE-Journal Papers(저널논문)EE-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 35 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0