Thermo-sensitive, injectable, and tissue adhesive sol-gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction

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Hyaluronic acid (HA) hydrogels are widely pursued as tissue regenerative and drug delivery materials due to their excellent biocompatibility and biodegradability. Inspired by mussel adhesion, we report here a novel class of thermo-sensitive and injectable HA/Pluronic F127 composite tissue-adhesive hydrogels applicable for various biomedical applications. HA conjugated with dopamine (HA-DN) was mixed with thiol end-capped Pluronic F127 copolymer (Plu-SH) to produce a lightly cross-linked HA/Pluronic composite gel structure based on Michael-type catechol-thiol addition reaction. The HA/Pluronic hydrogels exhibited temperature-dependent sol-gel phase transition behaviors different from Pluronic hydrogels. Rheological studies showed that the sol-gel transitions were rapid and reversible in response to temperature. The HA/Pluronic hydrogels could be injected in vivo in a sol state at room temperature using a syringe, but immediately became a robust gel state at body temperature. The in situ formed hydrogels exhibited excellent tissue-adhesion properties with superior in vivo gel stability and are potentially useful for drug and cell delivery.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2010
Language
English
Article Type
Article
Keywords

HUMAN GROWTH-HORMONE; MULTIBLOCK COPOLYMERS; ACID; DELIVERY; DOPAMINE; DEGRADATION; NETWORKS; BEHAVIOR; BRAIN; PH

Citation

SOFT MATTER, v.6, no.5, pp.977 - 983

ISSN
1744-683X
DOI
10.1039/b919944f
URI
http://hdl.handle.net/10203/97930
Appears in Collection
NT-Journal Papers(저널논문)CH-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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