DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Ji-Ho | ko |
dc.contributor.author | von Maltzahn, Geoffrey | ko |
dc.contributor.author | Xu, Mary Jue | ko |
dc.contributor.author | Fogal, Valentina | ko |
dc.contributor.author | Kotamraju, Venkata Ramana | ko |
dc.contributor.author | Ruoslahti, Erkki | ko |
dc.contributor.author | Bhatia, Sangeeta N. | ko |
dc.contributor.author | Sailor, Michael J. | ko |
dc.date.accessioned | 2013-03-11T01:13:04Z | - |
dc.date.available | 2013-03-11T01:13:04Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.3, pp.981 - 986 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97886 | - |
dc.description.abstract | A significant barrier to the clinical translation of systemically administered therapeutic nanoparticles is their tendency to be removed from circulation by the mononuclear phagocyte system. The addition of a targeting ligand that selectively interacts with cancer cells can improve the therapeutic efficacy of nanomaterials, although these systems have met with only limited success. Here, we present a cooperative nanosystem consisting of two discrete nanomaterials. The first component is gold nanorod (NR) "activators" that populate the porous tumor vessels and act as photothermal antennas to specify tumor heating via remote near-infrared laser irradiation. We find that local tumor heating accelerates the recruitment of the second component: a targeted nanoparticle consisting of either magnetic nanoworms (NW) or doxorubicin-loaded liposomes (LP). The targeting species employed in this work is a cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) that binds to the stress-related protein, p32, which we find to be upregulated on the surface of tumor-associated cells upon thermal treatment. Mice containing xenografted MDA-MB-435 tumors that are treated with the combined NR/LyP-1LP therapeutic system display significant reductions in tumor volume compared with individual nanoparticles or untargeted cooperative system. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | LARGE UNILAMELLAR VESICLES | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | HOMING PEPTIDE | - |
dc.subject | HYPERTHERMIA | - |
dc.subject | CANCER | - |
dc.subject | CELLS | - |
dc.subject | THERAPY | - |
dc.subject | MODEL | - |
dc.subject | SIZE | - |
dc.subject | NANOPARTICLES | - |
dc.title | Cooperative nanomaterial system to sensitize, target, and treat tumors | - |
dc.type | Article | - |
dc.identifier.wosid | 000273934100009 | - |
dc.identifier.scopusid | 2-s2.0-75749110220 | - |
dc.type.rims | ART | - |
dc.citation.volume | 107 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 981 | - |
dc.citation.endingpage | 986 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.0909565107 | - |
dc.contributor.localauthor | Park, Ji-Ho | - |
dc.contributor.nonIdAuthor | von Maltzahn, Geoffrey | - |
dc.contributor.nonIdAuthor | Xu, Mary Jue | - |
dc.contributor.nonIdAuthor | Fogal, Valentina | - |
dc.contributor.nonIdAuthor | Kotamraju, Venkata Ramana | - |
dc.contributor.nonIdAuthor | Ruoslahti, Erkki | - |
dc.contributor.nonIdAuthor | Bhatia, Sangeeta N. | - |
dc.contributor.nonIdAuthor | Sailor, Michael J. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | gold nanorods | - |
dc.subject.keywordAuthor | liposomes | - |
dc.subject.keywordAuthor | magnetic nanoworms | - |
dc.subject.keywordAuthor | protein expression | - |
dc.subject.keywordPlus | LARGE UNILAMELLAR VESICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | HOMING PEPTIDE | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.