DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, O | ko |
dc.contributor.author | Jeong, Y | ko |
dc.contributor.author | Lee, H | ko |
dc.contributor.author | Hong, SS | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.date.accessioned | 2013-03-11T01:11:47Z | - |
dc.date.available | 2013-03-11T01:11:47Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.citation | JOURNAL OF MEDICINAL CHEMISTRY, v.54, no.7, pp.2455 - 2466 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97883 | - |
dc.description.abstract | Phosphatidylinositol 3-kinase alpha (P13K alpha) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the P13K pathway is frequently up-regulated in human cancers, the inhibition of P13K alpha can be a promising approach to cancer therapy. In this study, we have designed and synthesized a new series of imidazo[1,2-a]pyridine derivatives as P13K alpha inhibitors through the fragment-growing strategy. By varying groups at the 3- and 6-positions of imidazo[1,2-a]pyridines, we studied the structure-activity relationships (SAR) profiles and identified a series of potent P13K alpha inhibitors. Representative derivatives showed good activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited note-worthy antiangiogenic activity. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | IN-VIVO | - |
dc.subject | CANCER | - |
dc.subject | POTENT | - |
dc.subject | IDENTIFICATION | - |
dc.subject | MUTATIONS | - |
dc.subject | DISCOVERY | - |
dc.subject | RAPAMYCIN | - |
dc.subject | ISOFORM | - |
dc.subject | PATHWAY | - |
dc.title | Design and Synthesis of Imidazopyridine Analogues as Inhibitors of Phosphoinositide 3-Kinase Signaling and Angiogenesis | - |
dc.type | Article | - |
dc.identifier.wosid | 000289215700041 | - |
dc.identifier.scopusid | 2-s2.0-79953777821 | - |
dc.type.rims | ART | - |
dc.citation.volume | 54 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 2455 | - |
dc.citation.endingpage | 2466 | - |
dc.citation.publicationname | JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.identifier.doi | 10.1021/jm101582z | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Lee, H | - |
dc.contributor.nonIdAuthor | Hong, SS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | RAPAMYCIN | - |
dc.subject.keywordPlus | ISOFORM | - |
dc.subject.keywordPlus | PATHWAY | - |
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